{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:43:28Z","timestamp":1773679408485,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T00:00:00Z","timestamp":1362960000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100006727","name":"University of Kansas Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Dietary dextrose and fructose may promote vascular inflammation and endothelial dysfunction. In certain infant populations, altered postprandial mesenteric hyperemia (PPH) may increase risk for feeding intolerance. <jats:italic>Objective<\/jats:italic>: To compare superior mesenteric artery (SMA) PPH following feeds of lactose\u2010containing (LC) formula vs lactose\u2010free (LF; dextrose + sucrose) formula. <jats:italic>Methods<\/jats:italic>: In a 2 \u00d7 2 crossover study with 6 term newborns, 3 received LC first followed by LF 3 hours later. The remaining 3 received the reverse order. Ultrasound measures of pre\u2010 and postprandial SMA flow, diameter, and resistance were taken 5 minutes preprandial and 10, 30, and 40 minutes postprandial. <jats:italic>Results<\/jats:italic>: Mean \u00b1 SD age and weight (n = 6) were 24.1 \u00b1 2.3 hours and 3.1 \u00b1 0.21 kg. Formula intake was similar for LC and LF (22.5 \u00b1 2.8 mL and 25 \u00b1 1.8 mL, respectively; <jats:italic>P =<\/jats:italic> .076). Both formulas increased SMA flow at 10 and 30 minutes. However, postprandial flow was greater for LC overall (<jats:italic>P =<\/jats:italic> .004) and especially at 30 minutes (LC 103 mL\/min, 52% increase vs LF 92.7 mL\/min, 31% increase; <jats:italic>P =<\/jats:italic> .014). For both formulas, vasodilation was seen at 10 and 30 minutes and was overall significantly greater following LC than following LF (9.1% vs 6.5%; <jats:italic>P<\/jats:italic> = .028). Both formulas elicited significant decreases in SMA vascular resistance over the 10\u2010 to 30\u2010minute period (overall <jats:italic>P<\/jats:italic> = .016). However, decreases did not differ across formulas (<jats:italic>P<\/jats:italic> = .672). <jats:italic>Conclusions<\/jats:italic>: The LC formula elicited a greater SMA PPH response than did LF. SMA flow for both formulas was within normal limits; thus, differences are likely inconsequential for a term newborn. However, in a vulnerable preterm infant, differences may become significant.<\/jats:p>","DOI":"10.1177\/0148607113478442","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T21:21:04Z","timestamp":1363036864000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Lactose\u2010Containing vs Lactose\u2010Free Infant Formula on Postprandial Superior Mesenteric Artery Flow in Term Infants"],"prefix":"10.1002","volume":"38","author":[{"given":"Valerie A.","family":"Schroeder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leone F.","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa A.","family":"Kilkenny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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