{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:04:40Z","timestamp":1787018680384,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["(AHA 10POST356001)"],"award-info":[{"award-number":["(AHA 10POST356001)"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["(R01 GM103799)"],"award-info":[{"award-number":["(R01 GM103799)"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    Sepsis is characterized by metabolic disturbances, and previous data suggest a relative carnitine deficiency may contribute to metabolic dysfunction. Studies regarding safety and patient\u2010centered efficacy of carnitine during septic shock are lacking.\n                    <jats:italic>Methods<\/jats:italic>\n                    : This was a double\u2010blind randomized control trial of levocarnitine (L\u2010carnitine) infusion vs normal saline for the treatment of vasopressor\u2010dependent septic shock. Patients meeting consensus definition for septic shock with a cumulative vasopressor index \u22653 and sequential organ failure assessment (SOFA) score \u22655 enrolled within 16 hours of the recognition of septic shock were eligible. The primary safety outcome was difference in serious adverse events (SAEs) per patient between groups. Efficacy outcomes included proportion of patients demonstrating a decrease in SOFA score of 2 or more points at 24 hours and short\u2010 and long\u2010term survival.\n                    <jats:italic>Results<\/jats:italic>\n                    : Of the 31 patients enrolled, 16 were in the L\u2010carnitine and 15 were in the placebo arm. There was no difference in SAEs between placebo and intervention (2.1 vs 1.8 SAEs per patient,\n                    <jats:italic>P<\/jats:italic>\n                    = .44). There was no difference in the proportion of patients achieving a decrease in SOFA score of 2 or more points at 24 hours between placebo and treatment (53% vs 44%,\n                    <jats:italic>P<\/jats:italic>\n                    = .59). Mortality was significantly lower at 28 days in the L\u2010carnitine group (4\/16 vs 9\/15,\n                    <jats:italic>P<\/jats:italic>\n                    = .048), with a nonsignificant improved survival at 1 year (\n                    <jats:italic>P<\/jats:italic>\n                    = .06).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : L\u2010carnitine infusion appears safe in vasopressor\u2010dependent septic shock. Preliminary efficacy data suggest potential benefit of L\u2010carnitine treatment, and further testing is indicated.\n                  <\/jats:p>","DOI":"10.1177\/0148607113495414","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T22:16:32Z","timestamp":1373667392000},"page":"736-743","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":52,"title":["Preliminary Safety and Efficacy of L\u2010carnitine Infusion for the Treatment of Vasopressor\u2010Dependent Septic Shock"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael A.","family":"Puskarich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Kline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Krabill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Claremont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.7.862"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103083441001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc1824"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0311133"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199608000-00002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607185009004483"},{"key":"e_1_2_8_9_1","first-page":"83","article-title":"Influence of acetyl\u2010L\u2010carnitine infusion on haemodynamic parameters and survival of circulatory\u2010shock patients","volume":"11","author":"Gasparetto A","year":"1991","journal-title":"Int J Clin Pharm Res"},{"key":"e_1_2_8_10_1","first-page":"1644","volume-title":"Chest","author":"Bone R","year":"1992"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_8_12_1","first-page":"A7","article-title":"Cumulative vasopressor index (CVI) as an assessment of cardiovascular organ dysfunction and indicator of outcome in patients with septic shock","volume":"35","author":"Siddiqui FS","year":"2007","journal-title":"Crit Care Med"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0234"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810625"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2003.08.008"},{"key":"e_1_2_8_16_1","unstructured":"FDA clinical review drotrecogin alfa (activated) [recombinant human activated protein C (rhAPC)] Xigris.2012.http:\/\/www.fda.gov\/downloads\/drugs\/developmentapprovalprocess\/howdrugsaredevelopedandapproved\/approvalapplications\/therapeuticbiologicapplications\/ucm113438.pdf"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.14.1754"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607113495414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607113495414","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607113495414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:53:01Z","timestamp":1760863981000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607113495414"}},"subtitle":["A Randomized Control Trial"],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1177\/0148607113495414"],"URL":"https:\/\/doi.org\/10.1177\/0148607113495414","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718031578.793482023","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718031578.793483273","asserted-by":"object"}]},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]}}}