{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:51:27Z","timestamp":1782507087857,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T00:00:00Z","timestamp":1407196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Despite the demonstrated dangers of inadequate supplies of injectable multivitamins, periodic shortages of these crucial pharmaceuticals continue to occur in the developed world. This case report provides a recent example of the potential danger of rationing parenteral multivitamins in chronically parenteral nutrition (PN)\u2013dependent patients in the setting of national supply shortages. <jats:italic>Method and Results:<\/jats:italic> Case report describing a chronically PN\u2010dependent 21\u2010year\u2010old man who presented with signs and symptoms of septic shock to a pediatric intensive care unit at a university hospital. The patient demonstrated hyperlactatemia that persisted following hemodynamic stabilization, and he was determined to be severely deficient in thiamin despite thrice\u2010weekly home multivitamin infusions, instead of daily due to national supply shortages. The patient's hyperlactatemia rapidly resolved following thiamine supplementation. <jats:italic>Conclusion:<\/jats:italic> Physicians must be vigilant for potentially life\u2010threatening nutrition deficiencies, as illustrated in this case of thiamine insufficiency, in PN\u2010dependent children and adults in the setting of nationwide limitations in multivitamin supply.<\/jats:p>","DOI":"10.1177\/0148607114545128","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T22:49:21Z","timestamp":1407278961000},"page":"604-606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Thiamin Deficiency as a Cause of Persistent Hyperlactatemia in a Parenteral Nutrition\u2013Dependent Patient"],"prefix":"10.1002","volume":"39","author":[{"given":"Yong Sing","family":"Da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Horvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Dezfulian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"issue":"3","key":"e_1_2_5_2_1","first-page":"43","article-title":"Deaths associated with thiamine\u2010deficient total parenteral nutrition","volume":"38","author":"Centers for Disease Control (CDC)","year":"1989","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"23","key":"e_1_2_5_3_1","first-page":"523","article-title":"Lactic acidosis traced to thiamine deficiency related to nationwide shortage of multivitamins for total parenteral nutrition\u2014United States, 1997","volume":"46","author":"Centers for Disease Control and Prevention (CDC)","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-227"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4065\/74.3.259"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.1.e10"},{"key":"e_1_2_5_7_1","author":"Multiple vitamins for infusion","journal-title":"Current Drug Shortage Bulletin"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370115"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1999.tb02092.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1112633"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/48.5.1324"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533612446706"},{"key":"e_1_2_5_13_1","unstructured":"A.S.P.E.N. Multivitamin Shortage Plan\u20142012.http:\/\/www.nutritioncare.org\/lcontent.aspx?id=5346. Accessed January 28 2014."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32834b8911"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-11-11"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2010.03.003"},{"key":"e_1_2_5_17_1","volume-title":"Tietz Textbook of Clinical Chemistry and Molecular Diagnostics","author":"Burtis CA","year":"2013"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.06.004"},{"key":"e_1_2_5_19_1","volume-title":"Dietary Reference Intakes the Essential Guide to Nutrient Requirements","author":"Otten JJ","year":"2006"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607114545128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607114545128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607114545128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:47:35Z","timestamp":1760878055000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607114545128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1177\/0148607114545128"],"URL":"https:\/\/doi.org\/10.1177\/0148607114545128","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]}}}