{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T09:59:41Z","timestamp":1768903181711,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T00:00:00Z","timestamp":1412294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T00:00:00Z","timestamp":1412294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Parenteral nutrition\u2010associated liver disease (PNALD) remains a significant cause of morbidity and mortality in neonates with intestinal failure. Although glucagon\u2010like peptide\u20102 (GLP\u20102) is being advanced as therapy, the effect of GLP\u20102 treatment on PNALD is unknown. We aim to investigate the effect of exogenous GLP\u20102 administration on hepatic function in a neonatal piglet model of PNALD. <jats:italic>Methods<\/jats:italic>: Neonatal piglets (aged 2\u20136 days) underwent jugular venous catheterization to receive isonitrogenous, isocaloric parenteral nutrition (PN). Piglets were allocated to 2 groups: group 1 (n = 8) received saline while group 2 (n = 7) received GLP\u20102 (at 11 nmol\/kg\/d). After 17 days, piglets underwent terminal laparotomy, and bile flow was measured. Liver specimens were analyzed histologically and with immunoperoxidase staining. Age\u2010matched sow\u2010reared control piglets (group 3, n = 8) were used for comparison. <jats:italic>Results<\/jats:italic>: Both groups 1 and 2 receiving PN developed cholestasis relative to sow\u2010reared controls, as evidenced by a decrease in bile flow and increase in serum total bilirubin. However, group 2 had improved bile flow (1.35 vs 0.73 \u00b5L\/g; <jats:italic>P<\/jats:italic> = .02) and diminished bilirubin (38.0 vs 78.5 \u00b5mol\/L; <jats:italic>P<\/jats:italic> = .008) compared with group 1. Group 2 also had lower serum alanine aminotransferase levels, a marker of liver injury. Histologically, the liver specimens in group 1 had marked hepatocyte pigmentation, which was decreased in group 2 specimens. <jats:italic>Conclusions<\/jats:italic>: The exogenous administration of GLP\u20102 is associated with the improvement of cholestasis and liver injury. This study introduces a novel role for GLP\u20102 in improving PNALD in the setting of prolonged PN duration.<\/jats:p>","DOI":"10.1177\/0148607114551968","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T23:15:53Z","timestamp":1412378153000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Glucagon\u2010Like Peptide 2 Improves Cholestasis in Parenteral Nutrition\u2013Associated Liver Disease"],"prefix":"10.1002","volume":"40","author":[{"given":"David W.","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Wales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica K.","family":"Josephson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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