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Goblet cells produce mucosal defense compounds, including mucin (principally MUC2), trefoil factor 3 (TFF3), and resistin\u2010like molecule \u03b2 (RELM\u03b2). Bombesin (BBS), a gastrin\u2010releasing peptide analogue, experimentally reverses PN\u2010induced defects in Paneth cell innate immunity. We hypothesized that PN reduces goblet cell product expression and PN+BBS would reverse these PN\u2010induced defects. <jats:italic>Methods<\/jats:italic>: Two days after intravenous cannulation, male Institute of Cancer Research mice were randomized to chow (n = 15), PN (n = 13), or PN+BBS (15 \u00b5g tid) (n = 12) diets for 5 days. Defined segments of ileum and luminal fluid were analyzed for MUC2, TFF3, and RELM\u03b2 by quantitative reverse transcriptase polymerase chain reaction and Western blot. Th2 cytokines interleukin (IL)\u20134 and IL\u201013 were measured by enzyme\u2010linked immunosorbent assay. <jats:italic>Results<\/jats:italic>: Compared with chow, PN significantly reduced MUC2 in ileum (<jats:italic>P<\/jats:italic> &lt; .01) and luminal fluid (<jats:italic>P<\/jats:italic> = .01). BBS supplementation did not improve ileal or luminal MUC2 compared with PN (<jats:italic>P<\/jats:italic> &gt; .3). Compared with chow, PN significantly reduced TFF3 in ileum (<jats:italic>P<\/jats:italic> &lt; .02) and luminal fluid (<jats:italic>P<\/jats:italic> &lt; .01). BBS addition did not improve ileal or luminal TFF3 compared with PN (<jats:italic>P<\/jats:italic> &gt; .3). Compared with chow, PN significantly reduced ileal RELM\u03b2 (<jats:italic>P<\/jats:italic> &lt; .01). BBS supplementation significantly increased ileal RELM\u03b2 to levels similar to chow (<jats:italic>P<\/jats:italic> &lt; .03 vs PN; <jats:italic>P<\/jats:italic> &gt; .6 vs chow). Th2 cytokines were decreased with PN and returned to chow levels with BBS. <jats:italic>Conclusion<\/jats:italic>: PN significantly impairs the goblet cell component of innate mucosal immunity. BBS only preserves goblet cell RELM\u03b2 during PN but not other goblet cell products measured.<\/jats:p>","DOI":"10.1177\/0148607115585353","type":"journal-article","created":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T21:22:21Z","timestamp":1430515341000},"page":"1042-1049","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Bombesin Preserves Goblet Cell Resistin\u2010Like Molecule \u03b2 During Parenteral Nutrition but Not Other Goblet Cell Products"],"prefix":"10.1002","volume":"40","author":[{"given":"Rebecca A.","family":"Busch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron F.","family":"Heneghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Pierre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua 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