{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:05:51Z","timestamp":1789517151071,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Patients with intestinal failure, who are dependent on parenteral nutrition (PN) to supplement their limited absorption of dietary nutrients, are subject to complications associated with long\u2010term PN therapy. Medication therapy that results in improved dietary nutrient absorption may enable these patients to reduce or even become independent from PN therapy and its related complications. The glucagon\u2010like peptide 2 (GLP\u20102) analogue teduglutide was approved for use in such patients by the U.S. Food and Drug Administration in 2012. <jats:italic>Purpose<\/jats:italic>: The purpose of this article is to describe the experience of 7 patients with PN\u2010dependent intestinal failure who were treated with teduglutide by a single center that had been involved in the teduglutide clinical trials. <jats:italic>Results<\/jats:italic>: Two patients who were treated during the clinical trials and 5 others who were treated since teduglutide came to market in the United States are described. Protocols used to prepare and monitor patients with this drug and PN weaning and adverse event outcomes are presented. <jats:italic>Conclusions<\/jats:italic>: While some patients had uncomplicated PN reduction, others experienced various complications. Careful monitoring of patients' clinical course is needed during drug therapy.<\/jats:p>","DOI":"10.1177\/0148607115594010","type":"journal-article","created":{"date-parts":[[2015,6,26]],"date-time":"2015-06-26T00:39:28Z","timestamp":1435279168000},"page":"1183-1190","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Management of Patients With Parenteral Nutrition\u2013Dependent Short Bowel Syndrome During Teduglutide Therapy"],"prefix":"10.1002","volume":"40","author":[{"given":"Charlene","family":"Compher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph I.","family":"Boullata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavia","family":"Pickett\u2010Blakely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Schiavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Stoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce P.","family":"Kinosian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.08.017"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2005.10.002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114520994"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.05.004"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.223255"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000046"},{"key":"e_1_2_13_8_1","unstructured":"Food and Drug Administration.FDA approves Gattex to treat short bowel syndrome.2012.http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/ucm333171.htm. 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