{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:27:09Z","timestamp":1791412029532,"version":"4.3.3"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002578","name":"American Dietetic Association Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002578","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> The objective of this study was to demonstrate the feasibility and associations with short\u2010term outcomes of a medical nutrition therapy (MNT) intervention in patients with systemic scleroderma (SSc). <jats:italic>Materials and Methods:<\/jats:italic> Eighteen patients with SSc, gastrointestinal (GI) involvement, and unintentional weight loss were consented and recruited for a 6\u2010week MNT intervention, in addition to their usual medical management. MNT emphasized increased calorie and protein intake, modified textures, and lifestyle modifications. Symptoms, anthropometrics, diet (24\u2010hour recall), and body composition (dual\u2010energy x\u2010ray absorptiometry) were assessed pre\u2010 and postintervention. Sarcopenia was defined as appendicular lean height (ALH) for women &lt;5.45 kg\/m<jats:sup>2<\/jats:sup> and for men &lt;7.26 kg\/m<jats:sup>2<\/jats:sup>. Descriptive, parametric, and nonparametric statistics were conducted. <jats:italic>Results:<\/jats:italic> Participants (n = 18) were predominantly white (78%), female (89%), malnourished (83%), and 51.3 \u00b1 11.0 years of age with a body mass index of 22.6 \u00b1 6.7 kg\/m<jats:sup>2<\/jats:sup>. Significant decreases in nutrition symptom scores (12.8 vs 7.6, <jats:italic>P<\/jats:italic> &lt; .05) and improvements in ALH (5.6 \u00b1 0.8 vs 5.8 \u00b1 0.8 kg\/m<jats:sup>2<\/jats:sup>, respectively; <jats:italic>P<\/jats:italic> = .05) occurred pre\u2010 vs postintervention, respectively (n = 14). Sarcopenia was observed in 54% of participants at baseline and 39% at follow\u2010up (<jats:italic>P<\/jats:italic> = .02). Caloric intake (1400 vs 1577 kcal\/d, <jats:italic>P<\/jats:italic> = .12) and macronutrient distribution (ie, % fat, protein, carbohydrate) did not change significantly pre\u2010 vs postintervention, respectively. <jats:italic>Conclusions:<\/jats:italic> Individually tailored MNT can improve symptom burden and potentially ALH in patients with SSc involving the GI tract. This study underscores the clinical potential of multidisciplinary patient management and the need for larger nutrition intervention trials of longer duration in these patients.<\/jats:p>","DOI":"10.1177\/0148607115597883","type":"journal-article","created":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T23:54:15Z","timestamp":1437782055000},"page":"678-684","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Medical Nutrition Therapy for Patients With Advanced Systemic Sclerosis (MNT PASS): A Pilot Intervention Study"],"prefix":"10.1002","volume":"41","author":[{"given":"Bethany","family":"Doerfler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara S.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Southwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Sheean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:3:1:035"},{"issue":"8","key":"e_1_2_8_3_1","first-page":"495","article-title":"Ischaemia of the small intestine in patients with systemic sclerosis: Raynaud's phenomenon or chronic vasculopathy?","volume":"87","author":"Kaye SA","year":"1994","journal-title":"QJM"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02804.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750026434"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090694"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem329"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.08.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013002147"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131547"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601412"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.755554"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.755554"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.09.027"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.5.1171"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/oso\/9780195171693.003.0003","volume-title":"Principles of Nutritional Assessment","author":"Gibson RS","year":"2005"},{"issue":"1","key":"e_1_2_8_17_1","first-page":"156","article-title":"An improved approach to 24\u2010hour dietary recall methodology","volume":"45","author":"Moshfegh AJ","year":"2011","journal-title":"Ann Nutr Metab"},{"key":"e_1_2_8_18_1","author":"Nutrition Coordinating Center","journal-title":"Nutrient Data System for Research"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009520"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860717700100101"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2710.1998.00125.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3067"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3148\/74.2.2013.69"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1525"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2005.07.005"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24730"},{"key":"e_1_2_8_28_1","unstructured":"GetzugT FathiN BechtelA FurstDE.Scoring guide UCLA Scleroderma Clinical Trial Consortium Gastrointestinal tract (UCLA CTC GIT 2.0) instrument.http:\/\/uclascleroderma.researchcore.org\/pdf\/scoringGuide.pdf. Accessed July 14 2015."},{"key":"e_1_2_8_29_1","unstructured":"Centers for Disease Control and Prevention.CDC HRQOL\u20104 \u201chealthy days\u201d measure.2015.http:\/\/www.cdc.gov\/hrqol\/hrqol14_measure.htm#1. Accessed June 15 2015."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-66"},{"issue":"58","key":"e_1_2_8_31_1","first-page":"S42","article-title":"Screening and management for malnutrition and related gastro\u2010intestinal disorders in systemic sclerosis: recommendations of a North American expert panel","volume":"28","author":"Baron M","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.04.013"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00098-0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.154"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2013.12.011"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123273"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112440285"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.06.016"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-012-0234-x"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2011.10.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2012-000419"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318289bb7e"},{"key":"e_1_2_8_43_1","article-title":"Nutrition intake and physical activity in a middle school in New York City","author":"Gonzalez M","year":"2014","journal-title":"Int J Adolesc Med Health"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2013.20.1.1"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0b013e328331124a"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1525"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0148607115597883","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0148607115597883","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607115597883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:13:44Z","timestamp":1760868824000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607115597883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,24]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1177\/0148607115597883"],"URL":"https:\/\/doi.org\/10.1177\/0148607115597883","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,24]]}}}