{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T19:11:47Z","timestamp":1771873907857,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T00:00:00Z","timestamp":1441670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Improvement of fat digestion and absorption was supposed to relieve feeding intolerance. This trial aimed to evaluate the effect of a fat\u2010modified enteral formula on feeding tolerance in critically ill patients. <jats:italic>Materials and Methods:<\/jats:italic> This trial was conducted in 7 hospitals in China. In total, 144 intensive care unit (ICU) patients with estimated need of enteral nutrition (EN) for at least 5 days were randomly given fat\u2010modified enteral formula containing medium\u2010chain triglycerides (MCT), carnitine, and taurine (interventional feed group, n = 71) or standard enteral formula (control feed group, n = 73). EN intake, feeding intolerance (diarrhea, vomiting, gastric retention, and abdominal distension) and outcomes (mechanical ventilator\u2010free days of 28 days, length of ICU stay, length of hospital stay, and in\u2010hospital mortality) were collected. <jats:italic>Results:<\/jats:italic> Daily calories and protein intake were increased in the interventional feed group compared with the control feed group (<jats:italic>P<\/jats:italic> &lt; .01). Total incidence of feeding intolerance was 42.3% in the interventional feed group and 65.7% in the control feed group (<jats:italic>P<\/jats:italic> &lt; .001). Daily incidence of feeding intolerance was 11.3%, 18.3%, 14.1%, 25.4%, and 26.1% in the interventional feed group and 31.5%, 32.9%, 34.2%, 34.2%, and 30.4% in the control feed group from study days 1\u20135 (<jats:italic>P<\/jats:italic> = .0083). Incidence of feeding intolerance without abdominal distention was 32.9% in the interventional feed group and 49.3% in the control feed group (<jats:italic>P<\/jats:italic> = .047), while the incidence of abdominal distension was 26.8% in the interventional feed group and 43.8% in the control feed group (<jats:italic>P<\/jats:italic> = .03). No significant differences existed in outcomes between the 2 groups. <jats:italic>Conclusions:<\/jats:italic> The fat\u2010modified enteral formula containing MCT, carnitine, and taurine may improve feeding tolerance in critically ill patients.<\/jats:p>","DOI":"10.1177\/0148607115601858","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T20:29:26Z","timestamp":1441744166000},"page":"785-795","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Fat\u2010Modified Enteral Formula Improves Feeding Tolerance in Critically Ill Patients: A Multicenter, Single\u2010Blind, Randomized Controlled 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