{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:30:06Z","timestamp":1782505806758,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T00:00:00Z","timestamp":1442361600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Intravenous nutrition preparations that are not photoprotected generate oxidants, which are deleterious for cell survival. The question remains: are these observations of clinical relevance in individuals receiving parenteral nutrition (PN), especially in those who exhibit immature antioxidant defenses such as premature infants? <jats:italic>Objective:<\/jats:italic> To review clinical trials reporting the effect of light\u2010exposed vs light\u2010protected PN to determine whether photoprotection reduces neonatal mortality in preterm infants. <jats:italic>Data source:<\/jats:italic> Electronic databases, abstracts in relevant journals, and references in manuscripts between 1980 and 2014. <jats:italic>Selection criteria:<\/jats:italic> Newborn, premature infants, PN, photoprotection, shielding from light, randomization, mortality, death. <jats:italic>Methods:<\/jats:italic> Consensus for inclusion reached by 2 reviewers; meta\u2010analysis of trials and observational studies reporting mortality at 36 weeks' gestational age or hospital discharge. <jats:italic>Results:<\/jats:italic> Four trials meeting selection criteria, which involved a total of 800 newborn premature infants, were included. Across trials, gestational age (mean \u00b1 SD) ranged from 26 \u00b1 1 to 31 \u00b1 2 weeks, birth weight from 775 \u00b1 161 to 1588 \u00b1 366 g, and mortality from 5%\u201332%. Mortality in the light\u2010protected group was half of that in the light\u2010exposed group (95% confidence interval, 0.32\u20130.87) and twice as high in males compared with females (\u03c7<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> = .01). <jats:italic>Conclusion:<\/jats:italic> Shielding PN from light has vital repercussions that call for action to provide photoprotected delivery systems and infusion sets in premature infants. Further studies should be extended to the increasing number of children and adults receiving long\u2010term home PN to evaluate the effects of light protection on severe complications that impede their quality of life.<\/jats:p>","DOI":"10.1177\/0148607115606407","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T23:58:57Z","timestamp":1442447937000},"page":"378-383","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Shielding Parenteral Nutrition From Light Improves Survival Rate in Premature Infants"],"prefix":"10.1002","volume":"41","author":[{"given":"Philippe","family":"Chessex","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Laborie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad","family":"Nasef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Masse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Lavoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.04.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087586"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000504.pub2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0850709"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb00298.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.05.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199805000-00007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2010.532791"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70412-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90031-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.070755"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200212000-00023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.135327"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818c8623"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2001.23188"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-14.3.132"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1865"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.04.029"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.07.018"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114537523"},{"key":"e_1_2_6_23_1","first-page":"139","article-title":"Photoprotection of parenteral nutrients enhances advancement of minimal enteral nutrition in preterm infants","author":"Khashu M","journal-title":"Semin Perinatol"},{"key":"e_1_2_6_24_1","unstructured":"The Canadian Neonatal Network Annual Report.http:\/\/www.canadianneonatalnetwork.org\/portal\/. 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