{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:00:12Z","timestamp":1773421212901,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T00:00:00Z","timestamp":1444867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003206","name":"Alberta Children\u2019s Hospital Foundation","doi-asserted-by":"publisher","award":["Professorship in Pediatric Surgery"],"award-info":[{"award-number":["Professorship in Pediatric Surgery"]}],"id":[{"id":"10.13039\/501100003206","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sidra Medical and Research Center","award":["Professorship in Pediatric Surgery"],"award-info":[{"award-number":["Professorship in Pediatric Surgery"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p><jats:italic>Background and Aims:<\/jats:italic> A glucagon\u2010like peptide 2 (GLP\u20102) analogue is approved for adults with intestinal failure, but no studies of GLP\u20102 have included children. This study examined the pharmacokinetics, safety, and nutritional effects of GLP\u20102 in children with intestinal failure. <jats:italic>Methods:<\/jats:italic> Native human GLP\u20102(1\u201033) was synthesized following good manufacturing practices. In an open\u2010label trial, with parental consent, 7 parenteral nutrition\u2013dependent pediatric patients were treated with subcutaneous GLP\u20102 (20 \u00b5g\/kg\/d) for 3 days (phase 1) and, if tolerated, continued for 42 days (phase 2). Nutritional treatment was directed by the primary caregivers. Patients were followed to 1 year. <jats:italic>Results:<\/jats:italic> Seven patients were enrolled (age: 4.0 \u00b1 0.8 years; bowel length, mean \u00b1 SEM: 24% \u00b1 4% of predicted). All were parenteral nutrition dependent since birth, receiving 44% \u00b1 5% of calories by parenteral nutrition. GLP\u20102 treatment had no effect on vital signs (blood pressure, heart rate, and temperature) and caused no significant adverse events. Peak GLP\u20102 levels were 380 pM (day 3) and 295 pM (day 42), with no change in half\u2010life or endogenous GLP\u20102 levels. Nutritional indices showed a numeric improvement in <jats:italic>z<\/jats:italic> scores and citrulline levels; the <jats:italic>z<\/jats:italic> score was maintained while citrulline levels returned to baseline once GLP\u20102 was discontinued. <jats:italic>Conclusions:<\/jats:italic> GLP\u20102 was well tolerated in children, with a pharmacokinetic profile similar to that of adults. There were no changes in endogenous GLP\u20102 release or metabolism. These results suggest that GLP\u20102 ligands may be safely used in pediatric patients; larger trials are suggested to investigate nutritional effects.<\/jats:p>","DOI":"10.1177\/0148607115609566","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T22:18:32Z","timestamp":1444947512000},"page":"844-852","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Safety and Dosing Study of Glucagon\u2010Like Peptide 2 in Children With Intestinal Failure"],"prefix":"10.1002","volume":"41","author":[{"given":"David 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