{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:41:42Z","timestamp":1760920902740,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008454","name":"American Society for Parenteral and Enteral Nutrition Rhoads Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008454","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008454","name":"American Society for Parenteral and Enteral Nutrition Rhoads Research Foundation","doi-asserted-by":"publisher","award":["Maurice Shils Grant"],"award-info":[{"award-number":["Maurice Shils Grant"]}],"id":[{"id":"10.13039\/100008454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>: Data are limited on how short bowel syndrome (SBS) affects the healthy developing intestinal microbiome, with even less assessing different SBS anatomical surgical models. This study was conducted to describe the \u201cileal\u201d and \u201ccolonic\u201d microflora in 2 surgical models of SBS. <jats:italic>Materials and Methods<\/jats:italic>: Neonatal piglets (2\u20135 days old) underwent intestinal resection, leaving the ileum (JI anatomy, n = 6) or removing the ileum and ileocecal valve (JC anatomy, n = 5), or sham surgery (sham; n = 4). JI, JC, and sham piglets commenced parenteral nutrition on day 0 and received ampicillin and trimethoprim\u2010sulfadoxine on days 0\u20134 for prevention of line sepsis. At day 7, ileal and colonic digesta were collected, and they were also collected from age\u2010matched sow\u2010fed piglets (n = 6). DNA extraction, sequencing, and annotation followed standard procedures. <jats:italic>Results<\/jats:italic>: Colonic and ileal bacterial genus diversity and relative bacterial abundance were greater (<jats:italic>P<\/jats:italic> &lt; .05) in sow\u2010fed compared with JI, JC, and sham piglets; however, minor differences were observed in either location between sham, JI, and JC piglets and within the surgical model. In the colon, sow\u2010fed piglets had higher (<jats:italic>P<\/jats:italic> &lt; .05) abundance of <jats:italic>Lactobacillus<\/jats:italic> (26%) and tended to have lower (<jats:italic>P<\/jats:italic> = .06) abundance of <jats:italic>Enterococcus<\/jats:italic> (&lt;.1%) than JI, JC, or sham piglets, in which <jats:italic>Lactobacillus<\/jats:italic> and <jats:italic>Enterococcus<\/jats:italic> abundance averaged &lt;.1% and 9%, respectively. <jats:italic>Conclusions<\/jats:italic>: Intestinal resection reduces bacterial diversity in the large bowel, and the difference is associated with the presence\/absence of the ileum and ileocecal valve. The lack of enteral nutrition and antibiotic administration (ie, sow\u2010fed vs surgery) had a greater influence on the observed shift in diversity and relative abundance than intestinal resection.<\/jats:p>","DOI":"10.1177\/0148607115626903","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T22:59:21Z","timestamp":1454453961000},"page":"938-945","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["In a Neonatal Piglet Model of Intestinal Failure, Administration of Antibiotics and Lack of Enteral Nutrition Have a Greater Impact on Intestinal Microflora Than Surgical Resection Alone"],"prefix":"10.1002","volume":"41","author":[{"given":"Crystal 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