{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:17:56Z","timestamp":1760919476152,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","award":["UNIK programme"],"award-info":[{"award-number":["UNIK programme"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Danish Research Councils"},{"DOI":"10.13039\/501100001734","name":"University of Copenhagen","doi-asserted-by":"crossref","award":["the UNIK programme"],"award-info":[{"award-number":["the UNIK programme"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p><jats:italic>Background:<\/jats:italic> Exogenous glucagon\u2010like peptide 2 (GLP\u20102) stimulates intestinal adaptation after resection in animal models of pediatric short bowel syndrome (SBS). It is unknown whether the molecular mechanisms of such GLP\u20102 effects are similar to those of postresection spontaneous adaptation. Using preterm pigs as a model, we hypothesized that GLP\u20102 treatment would change the intestinal proteome within the first week after resection, relative to individuals not resected or resected without GLP\u20102 treatment. <jats:italic>Materials and Methods:<\/jats:italic> Two\u2010day\u2010old preterm pigs were subjected to resection of 50% distal small intestine and fed total parenteral nutrition without (SBS) or with GLP\u20102 infusion (3.5 \u00b5g\/kg\/h, SBS+GLP\u20102) for 5 days. The proteome of the remnant proximal intestine was compared among the SBS, SBS+GLP\u20102, and unresected pigs, through gel\u2010based proteomics. <jats:italic>Results:<\/jats:italic> Thirty\u2010two proteins with differential expression were identified. Ten of these proteins were affected by the resection alone (ie, SBS vs unresected pigs). Five of these resection\u2010responsive proteins and another 22 proteins were affected by GLP\u20102 infusion (ie, SBS+GLP\u20102 vs SBS or unresected pigs). Resection alone mainly affected cellular structural proteins, while the added GLP\u20102 treatment affected proteins involved in protein processing and the metabolism of protein, carbohydrate, and sulphur. <jats:italic>Conclusion:<\/jats:italic> In the first days following resection, proteins affected by resection plus GLP\u20102 treatment differed markedly from those affected by the spontaneous intestinal adaptation following resection alone. Whether more long\u2010term GLP\u20102 treatment may affect the intestinal proteome following intestinal resection remains unknown.<\/jats:p>","DOI":"10.1177\/0148607116662971","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T23:13:10Z","timestamp":1470697990000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Glucagon\u2010Like Peptide 2 Stimulates Postresection Intestinal Adaptation in Preterm Pigs by Affecting Proteins Related to Protein, Carbohydrate, and Sulphur Metabolism"],"prefix":"10.1002","volume":"41","author":[{"given":"Pingping","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Vegge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Thymann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Man\u2010Fan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Torp","family":"Sangild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00064.2013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-002-0085-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00088.2014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f18ca0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2004.01.036"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.062"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22555"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000304449.46434.06"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.97"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.5.G911"},{"key":"e_1_2_7_12_1","article-title":"A safety and dosing study of glucagon\u2010like peptide\u20102 in children with intestinal failure","author":"Sigalet DL","year":"2015","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114554621"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr800638w"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2"},{"key":"e_1_2_7_16_1","unstructured":"R: A language and environment for statistical computing 2013 R Foundation for Statistical Computing Vienna Austria"},{"key":"e_1_2_7_17_1","unstructured":"R Studio: Integrated development for R 2012 RStudio Inc Boston MA"},{"key":"e_1_2_7_18_1","unstructured":"MetStaT: Statistical metabolomics tools[computer program]. 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