{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:30Z","timestamp":1790621010402,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    : An impaired hormonal \u201cileo\u2010colonic brake\u201d may contribute to rapid gastric emptying, gastric hypersecretion, high ostomy losses, and the need for parenteral support in end\u2010jejunostomy short bowel syndrome (SBS) patients with intestinal failure (IF). Liraglutide, a glucagon\u2010like peptide 1 receptor agonist, may reduce gastric hypersecretion and dampen gastric emptying, thereby improving conditions for intestinal absorption.\n                    <jats:italic>Materials and Methods<\/jats:italic>\n                    : In an 8\u2010week, open\u2010label pilot study, liraglutide was given subcutaneously once daily to 8 end\u2010jejunostomy patients, aged 63.4 \u00b1 10.9 years (mean \u00b1 SD) and with small bowel lengths of 110 \u00b1 66 cm. The 72\u2010hour metabolic balance studies were performed before and at the end of treatment. Food intake was unrestricted. Oral fluid intake and parenteral support volume were kept constant. The primary end point was change in the ostomy wet weight output.\n                    <jats:italic>Results<\/jats:italic>\n                    : Liraglutide reduced ostomy wet weight output by 474 \u00b1 563 g\/d from 3249 \u00b1 1352 to 2775 \u00b1 1187 g\/d (\n                    <jats:italic>P =<\/jats:italic>\n                    .049, Student\n                    <jats:italic>t<\/jats:italic>\n                    test). Intestinal wet weight absorption tended to increase by 464 \u00b1 557 g\/d (\n                    <jats:italic>P<\/jats:italic>\n                    = .05), as did urine production by 765 \u00b1 759 g\/d (\n                    <jats:italic>P =<\/jats:italic>\n                    .02). Intestinal energy absorption improved by 902 \u00b1 882 kJ\/d (\n                    <jats:italic>P<\/jats:italic>\n                    = .02).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Liraglutide reduced ostomy wet weight output in end\u2010jejunostomy patients with SBS\u2010IF and increased their intestinal wet weight and energy absorption. If larger, randomized, placebo\u2010controlled studies confirm these effects, it adds to the hypothesis that many ileo\u2010colonic brake hormones in conjunction may be involved in the process of intestinal adaptation. By identification of key hormones and addressing their potential synergistic effects, better treatments may be provided to patients with SBS\u2010IF. This trial was registered at clinicaltrialsregister.eu as 2013\u2010005499\u201016.\n                  <\/jats:p>","DOI":"10.1177\/0148607116672265","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T23:28:24Z","timestamp":1475537304000},"page":"112-121","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":65,"title":["Effect of Liraglutide Treatment on Jejunostomy Output in Patients With Short Bowel Syndrome: An Open\u2010Label Pilot Study"],"prefix":"10.1002","volume":"42","author":[{"given":"Mark","family":"Hvistendahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Filtenborg","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"Tribler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahim Mohammad","family":"Naimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolette","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Juul","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Frederik","family":"Rehfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Hornum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Rikardt","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birthe Merete","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Br\u00f8bech Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle Bekker","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.9.1171"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.15.3.229"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.33.11.1493"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.4.559"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22555"},{"key":"e_1_2_8_7_1","first-page":"425759","article-title":"Short bowel patients treated for two years with glucagon\u2010like peptide 2 (GLP\u20102): compliance, safety, and effects on quality of life","volume":"2009","author":"Jeppesen PB","year":"2009","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061440"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.029"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.06.018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.059741"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709025098"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2013.03.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01723.x"},{"key":"e_1_2_8_17_1","article-title":"Inside the pricing of a $300,000\u2010a\u2010year drug","author":"Herper M.","journal-title":"Forbes"},{"key":"e_1_2_8_18_1","article-title":"A single\u2010center, adult chronic intestinal failure cohort analyzed according to the ESPEN endorsed recommendations, definitions and classifications [published online October 20, 2015]","author":"Brandt C","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"e_1_2_8_19_1","unstructured":"Amgros.Sygehusmedicin 2015. 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