{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:43:51Z","timestamp":1790621031915,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"NPS Pharmaceuticals, Inc. a wholly owned indirect subsidiary of Shire."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>\n                    <jats:italic>Background:<\/jats:italic>\n                    In phase III clinical studies, treatment with teduglutide was associated with clinically meaningful reductions (\u226520% from baseline) in parenteral support (PS; parenteral nutrition and\/or intravenous fluids) requirements in adult patients with intestinal failure associated with short bowel syndrome (SBS\u2010IF). This analysis reports clinical characteristics of patients who achieved complete independence from PS during teduglutide treatment.\n                    <jats:italic>Materials and Methods:<\/jats:italic>\n                    Post hoc analysis of adult patients who achieved complete PS independence during treatment with teduglutide 0.05 mg\/kg\/d. Data were pooled from 5 teduglutide clinical trials (2 phase III placebo\u2010controlled trials [NCT00081458 and NCT00798967] and their respective extension studies [NCT00172185, NCT00930644, NCT01560403]). Descriptive statistics were used; no between\u2010group comparisons were performed because of the small sample size and lack of comparator.\n                    <jats:italic>Results:<\/jats:italic>\n                    Of 134 patients, 16 gained oral or enteral autonomy after a median of 5 years of PS dependence and 89 weeks of teduglutide treatment. Demographic and baseline disease characteristics varied among patients (median age, 55 years; 50% men; median baseline PS volume, 5.1 L\/wk; median residual small intestine length, 52.5 cm). Most patients who achieved PS independence had colon\u2010in\u2010continuity; however, there was no significant difference in the frequency of PS independence among patients who maintained colon\u2010in\u2010continuity vs those who did not.\n                    <jats:italic>Conclusion:<\/jats:italic>\n                    Findings from this post hoc analysis suggest that oral or enteral autonomy is possible for some patients with SBS\u2010IF who are treated with teduglutide, regardless of baseline characteristics and despite long\u2010term PS dependence.\n                  <\/jats:p>","DOI":"10.1177\/0148607116680791","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T22:04:26Z","timestamp":1479852266000},"page":"946-951","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":86,"title":["Independence From Parenteral Nutrition and Intravenous Fluid Support During Treatment With Teduglutide Among Patients With Intestinal Failure Associated With Short Bowel Syndrome"],"prefix":"10.1002","volume":"41","author":[{"given":"Kishore R.","family":"Iyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Kunecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph I.","family":"Boullata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Fujioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich\u2010Frank","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane M.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Nuria","family":"Virgili Casas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader N.","family":"Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle B.","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114520994"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607113517717"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.061440"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.218271"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(14)50437-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.029"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.69"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802078325"},{"key":"e_1_2_8_11_1","unstructured":"GATTEX (teduglutide [rDNA origin]) [full prescribing information] 2016 Shire\u2010NPS Pharmaceuticals Inc Lexington MA"},{"key":"e_1_2_8_12_1","unstructured":"Revestive (teduglutide) [EMA summary of product characteristics] 2016 NPS Pharma Holdings Limited Dublin Ireland"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.08.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607196020004275"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111414431"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607112469818"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114525210"}],"container-title":["Journal of Parenteral and Enteral 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