{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:16:54Z","timestamp":1790518614965,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Fasting plasma citrulline (p\u2010citrulline) is a marker of functional enterocyte mass. However, the optimal timing of measurement in relation to meals has yet to be clarified. Furthermore, p\u2010citrulline has been proposed to be a surrogate marker for small bowel length and intestinal absorption parameters in short bowel syndrome patients with intestinal failure (SBS\u2010IF). <jats:italic>Materials and Methods<\/jats:italic>: Eight patients with SBS\u2010IF and 8 healthy controls (HCs) were given a standardized mixed test meal, and p\u2010citrulline was measured 15 minutes before and 60, 120, and 180 minutes after completion of the meal. The patients with SBS\u2010IF had their intestinal absorption of wet weight, energy, macronutrients, and electrolytes measured in relation to 72\u2010hour metabolic balance studies. We investigated the possible correlations between p\u2010citrulline and short bowel length, absorptive parameters, and the dependence on parenteral support (PS). <jats:italic>Results<\/jats:italic>: In the patients with SBS\u2010IF, we found a 12% (<jats:italic>P<\/jats:italic> = .041) reduction in postprandial citrulline levels after 180 minutes. In the HCs, there was a 13% postprandial reduction at 60 minutes (<jats:italic>P<\/jats:italic> = .018). No significant correlations between fasting p\u2010citrulline and bowel length, bowel absorptive function, or the dependence on PS were found. Even when excluding 2 patients in whom the intestinal absorption was adjacent to the intestinal insufficiency borderlines, these correlations were not significant. <jats:italic>Conclusion<\/jats:italic>: Based on findings in this small study, the optimal timing of p\u2010citrulline measurement is on fasting samples. However, p\u2010citrulline seems insufficiently discriminative to serve as a valid biomarker of bowel length, bowel absorptive function, or dependence on PS in patients with SBS\u2010IF.<\/jats:p>","DOI":"10.1177\/0148607116687497","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T09:53:05Z","timestamp":1483782785000},"page":"418-426","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Fasting and Postprandial Plasma Citrulline and the Correlation to Intestinal Function Evaluated by 72\u2010Hour Metabolic Balance Studies in Short Bowel Jejunostomy Patients With Intestinal Failure"],"prefix":"10.1002","volume":"42","author":[{"given":"Hilde","family":"Fjermestad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hvistendahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle 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