{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T19:00:08Z","timestamp":1763578808367,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Minimal enteral nutrition (MEN) may induce a diet\u2010dependent stimulation of gut adaptation following intestinal resection. Bovine colostrum is rich in growth factors, and we hypothesized that MEN with colostrum would stimulate intestinal adaptation, compared with formula, and would be well tolerated in patients with short bowel syndrome. <jats:italic>Methods<\/jats:italic>: In experiment 1, 3\u2010day\u2010old piglets with 50% distal small intestinal resection were fed parenteral nutrition (PN, n = 10) or PN plus MEN given as either colostrum (PN\u2010COL, n = 5) or formula (PN\u2010FORM, n = 9) for 7 days. Intestinal nutrient absorption and histomorphometry were performed. In experiment 2, tolerance and feasibility of colostrum supplementation were tested in a pilot study on 5 infants who had undergone intestinal resection, and they were compared with 5 resected infants who served as controls. <jats:italic>Results<\/jats:italic>: In experiment 1, relative wet\u2010weight absorption and intestinal villus height were higher in PN\u2010COL vs PN (53% vs 23% and 362 \u00b1 13 vs 329 \u00b1 7 \u00b5m, <jats:italic>P<\/jats:italic> &lt; .05). Crypt depth and tissue protein synthesis were higher in PN\u2010COL (233 \u00b1 7 \u00b5m, 22%\/d) and PN\u2010FORM (262 \u00b1 13 \u00b5m, 22%\/d) vs PN (190 \u00b1 4 \u00b5m, 9%\/d, both <jats:italic>P<\/jats:italic> &lt; .05). In experiment 2, enteral colostrum supplementation was well tolerated, and no infants developed clinical signs of cow\u2019s milk allergy. <jats:italic>Conclusion<\/jats:italic>: Minimal enteral nutrition feeding with bovine colostrum and formula induced similar intestinal adaptation after resection in piglets. Colostrum was well tolerated by newly resected infants, but the clinical indication for colostrum supplementation to infants subjected to intestinal resection remains to be determined.<\/jats:p>","DOI":"10.1177\/0148607117690527","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T18:27:30Z","timestamp":1487874450000},"page":"446-454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Minimal Enteral Nutrition to Improve Adaptation After Intestinal Resection in Piglets and Infants"],"prefix":"10.1002","volume":"42","author":[{"given":"Lise","family":"Aunsholt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Qvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per T.","family":"Sangild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Vegge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas G.","family":"Burrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palle Bekker","family":"Jeppesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Husby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Thymann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,20]]},"reference":[{"issue":"22","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1001\/jama.1978.03290220064019","article-title":"Preventing necrotizing enterocolitis in neonates","volume":"240","author":"Brown EG","year":"1978","journal-title":"JAMA"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.3.461"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.6.1467"},{"issue":"12","key":"e_1_2_6_5_1","first-page":"3786","article-title":"Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs","volume":"132","author":"Sangild PT","year":"2002","journal-title":"J Nutr"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020623101106"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830100695"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.82.1.F29"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80646-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903510317"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.1.5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0958-6946(02)00089-4"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90452-H"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(03)73789-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110377206"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07565.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb00896.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.02.026"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00064.2013"},{"issue":"6","key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/MPG.0000000000000295","article-title":"Acute effects of the glucagon\u2010like peptide 2 analogue, teduglutide, on intestinal adaptation in newborn pigs with short bowel syndrome","volume":"58","author":"Thymann TS","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114528714"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/45.2.423"},{"issue":"1","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0021-9258(18)57092-7","article-title":"Rapid method for the determination of fat in feces","volume":"177","author":"Van De","year":"1949","journal-title":"J Biol Chem"},{"key":"e_1_2_6_25_1","unstructured":"MunroHN CrimMC.The proteins and amino acids. 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