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Outcomes were presented by mean differences, odds ratios, and corresponding 95% credible intervals for continuous outcomes and binary outcomes, respectively. Each therapy was ranked according to the value of surface under the cumulative ranking curve. Consistencies between direct and indirect comparisons were assessed with a node\u2010splitting plot. <jats:italic>Results<\/jats:italic>: In terms of efficacy end points (including levels of serum phosphate, serum calcium, serum intact parathyroid hormone, and serum calcium \u00d7 phosphorus product), all 7 kinds of agents outperformed or performed at least equally to placebo, with iron\u2010based phosphate\u2010binding agents being potentially the most effective. As for safety end points (including mortality, adverse events, and all\u2010cause discontinuation), almost all agents were equivalent in term of mortality and all\u2010cause discontinuation except in the comparison between iron\u2010based phosphate\u2010binding agents and placebo. Meanwhile, iron\u2010based phosphate\u2010binding agents colestilan and nicotinic acid performed poorly compared with placebo in terms of adverse events. Furthermore, iron\u2010based phosphate\u2010binding agents were potentially the safest agents followed sequentially by calcium\u2010based phosphate\u2010binding agents and placebo. <jats:italic>Conclusion<\/jats:italic>: Iron\u2010based phosphate\u2010binding agents were the preferable agents when considering efficacy and safety simultaneously.<\/jats:p>","DOI":"10.1177\/0148607117715440","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T19:34:14Z","timestamp":1501875254000},"page":"766-777","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative Efficacy and Safety of Phosphate Binders in Hyperphosphatemia Patients With Chronic Kidney 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