{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:19:19Z","timestamp":1760919559642,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: Intestinal failure\u2013associated liver disease (IFALD) causes significant morbidity in neonates with short bowel syndrome (SBS) dependent on parenteral nutrition (PN). Resected ileum, with loss of the ileocecal valve (ICV), is the most common anatomy in SBS, yet its impact on IFALD has not been adequately studied. <jats:italic>Methods<\/jats:italic>: Neonatal piglets were randomized to 75% intestinal resection with jejunocolic anastomosis (JC, n\u00a0=\u00a012), 75% resection with jejunoileal anastomosis and intact ICV (JI, n\u00a0=\u00a013), PN\u2010fed sham (sham, n\u00a0=\u00a014), or sow\u2010fed control (SF, n\u00a0=\u00a08). Surgical and sham piglets received 100% PN for 14 days before bile flow was measured and blood chemistry, liver pathology, jejunal permeability, and bacterial translocation were assessed. <jats:italic>Results<\/jats:italic>: Bile flow was lower for PN\u2010fed compared with SF (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) but not different between the PN\u2010fed groups. Total bilirubin (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and liver pathology (<jats:italic>P<\/jats:italic> &lt; .001) were greater in PN\u2010fed than SF groups but not different between PN\u2010fed groups. Serum bile acids were increased in sham (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) but not different between SBS groups. PN\u2010fed piglets with sepsis had lower bile flow (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and increased bilirubin (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Neither jejunal permeability nor bacterial translocation were different between JC, JI, or sham groups. <jats:italic>Conclusion<\/jats:italic>: Contrary to our hypothesis, the remnant anatomy does not appear to worsen the progression of IFALD. However, the role of sepsis in IFALD should be further explored, in addition to other mechanisms, including PN factors, host immune responses, and intestinal bacterial dysbiosis.<\/jats:p>","DOI":"10.1177\/0148607117718478","type":"journal-article","created":{"date-parts":[[2017,7,20]],"date-time":"2017-07-20T12:24:10Z","timestamp":1500553450000},"page":"14-23","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Surgical Anatomy Does Not Affect the Progression of Intestinal Failure\u2013Associated Liver Disease in Neonatal Piglets"],"prefix":"10.1002","volume":"42","author":[{"given":"Celeste M.","family":"Lavallee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela R.","family":"Wizzard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marihan","family":"Lansing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna F.","family":"Vine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick N.","family":"Nation","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Y.","family":"Yap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin P.","family":"Willing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul W.","family":"Wales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine M.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114527772"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2009.11.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13147"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607111413598"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31827e208c"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(92)90859-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26360"},{"issue":"4","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-2008-1072251","article-title":"Morbidity and mortality of the short\u2010bowel syndrome","volume":"9","author":"Mayr JM","year":"1999","journal-title":"Eur J Pediatr Surg"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2016.07.018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13383"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00311.2014"},{"issue":"3","key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1053\/jpsu.2002.30807","article-title":"Intestinal permeability and bacterial translocation are uncoupled after small bowel resection","volume":"37","author":"O\u2019Brien DP","year":"2002","journal-title":"J Pediatr Surg"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31819a4dff"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.01.004"},{"key":"e_1_2_8_16_1","article-title":"Glucagon\u2010like peptide 2 improves cholestasis in parenteral nutrition\u2013associated liver disease","author":"Lim DW","year":"2014","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.7.1248"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607114556494"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f18ca0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"e_1_2_8_21_1","article-title":"Synergy of glucagon\u2010like peptide\u20102 and epidermal growth factor co\u2010administration on intestinal adaptation in neonatal piglets with short bowel syndrome","author":"Lim DW","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021779159"},{"volume-title":"R: A Language and Environment for Statistical Computing","year":"2015","author":"R Core Team","key":"e_1_2_8_23_1"},{"volume-title":"An {R} Companion to Applied Regression","year":"2011","author":"Fox J","key":"e_1_2_8_24_1"},{"journal-title":"agricolae: Statistical Procedures for Agricultural Research. 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