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Copper deficiency presents a more uniform picture of hematologic abnormalities, usually anemia with leukopenia and neutropenia. Chromium and selenium deficiencies occur much less frequently, but well\u2010documented cases have been reported. We currently recommend regular monitoring and supplementation of these four trace metals during TPN administration. This article describes the clinical abnormalities that may develop when deficiencies of trace metals occur during TPN administration, and we present recommendations for trace metal supplementation during TPN administration.<\/jats:p>","DOI":"10.1177\/0148607181005005424","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"424-429","source":"Crossref","is-referenced-by-count":22,"title":["Trace Metal Abnormalities in Adults During Hyperalimentation"],"prefix":"10.1002","volume":"5","author":[{"given":"Craig J.","family":"Mcclain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31851-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/ajcn\/20.5.422","article-title":"Human zinc deficiency, endocrine manifestations and response to treatment","volume":"20","author":"Sandstead HH","year":"1967","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19790140"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197611000-00004"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196703000-00015"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ajcn\/23.5.514","article-title":"Zinc and wound healing","volume":"23","author":"Sandstead HH","year":"1970","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)92143-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01011961"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/archderm.1977.01640040030002","article-title":"Zinc correction of defective chemotaxis in acrodermatitis enteropathica","volume":"113","author":"Weston WL","year":"1977","journal-title":"Arch Dermatol"},{"key":"e_1_2_1_11_1","first-page":"605","article-title":"Zinc deficiency and intravenous feeding","volume":"2","author":"Kay RG","year":"1975","journal-title":"Lancet"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1001\/jama.1971.03190040028006","article-title":"Idiopathic hypogeusia with dysgeusia, hyposmia and dysosmia. 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