{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:22:17Z","timestamp":1787242937166,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1982,5,1]],"date-time":"1982-05-01T00:00:00Z","timestamp":389059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1982,5]]},"abstract":"<jats:p>Ten pediatric patients, aged 8.5\u201319 years, with active symptomatic Crohn's disease, received a three\u2010week period of continuous elemental enteral alimentation with no other form of treatment. All patients in this study were selected according to the following criteria, which were applied consecutively : (1) newly diagnosed patients with no previous treatment for Crohn's disease, (2) disease activity index over 200, and (3) no complication requiring surgery.<\/jats:p>\n                  <jats:p>All patients experienced a clinical remission and improved their immunologic and nutritional status during the elemental enteral alimentation. The mean disease activity index for the whole group was 307.0 \u00b1 23.6 (range: 203 to 413) before and 69.2 \u00b1 11.4 (range: 15 to 114) after the feeding period. Significant increases in body weight, triceps skinfold, mid\u2010arm circumference, serum transferrin and mean percentage of T lymphocytes were also observed. Following cessation of enteral alimentation, a small declining dose of prednisone was used during a one\u2010year follow\u2010up period. Eight of the ten patients were still in clinical remission three months after the feeding period and their nutritional status had continued to improve during that period of time.<\/jats:p>","DOI":"10.1177\/0148607182006003194","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"194-199","source":"Crossref","is-referenced-by-count":53,"title":["Continuous Elemental Enteral Alimentation in the Treatment of Children and Adolescents with Crohn's Disease"],"prefix":"10.1002","volume":"6","author":[{"given":"Claude L.","family":"Morin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Roulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude C.","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9e","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Normand","family":"Lapointe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1982,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(73)90022-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(76)90096-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01072033"},{"key":"e_1_2_1_5_1","first-page":"214","volume-title":"Advances in Experimental Medicine and Biology, vol 46","author":"Cohen MI","year":"1974"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1974.01350280066012"},{"key":"e_1_2_1_7_1","first-page":"313","article-title":"Parenteral hyperalimentation","volume":"62","author":"Myers RN","year":"1974","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02590975"},{"key":"e_1_2_1_9_1","first-page":"193","volume-title":"Gastrointestinal Emergencies","author":"Dudrick SJ","year":"1976"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0016-5085(76)80039-X","article-title":"Total parenteral nutrition at home. Studies in patients surviving 4 months to 5 years","volume":"1","author":"Jeejeebhoy KN","year":"1976","journal-title":"Gastroenterotogy"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31831-4"},{"key":"e_1_2_1_12_1","first-page":"108","article-title":"Nutritional management of granulomatous colitis with perineal ulceration","volume":"15","author":"Bury KD","year":"1972","journal-title":"Can J Surg"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01073162"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1973.01350200189039"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(74)90299-2"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)93159-7"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/00365521.1977.12031117","article-title":"Assessment of the therapeutic value of an elemental diet in chronic inflammatory bowel disease","volume":"12","author":"Axelsson C.","year":"1977","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90307-5"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19790064"},{"key":"e_1_2_1_20_1","first-page":"405","article-title":"Nasogastric infusion of elemental diet as primary therapy in Crohn's disease","volume":"13","author":"Morin CL","year":"1979","journal-title":"Ped Res"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","article-title":"Development of a Crohn's disease activity index","volume":"70","author":"Best WR","year":"1976","journal-title":"Gastroenterology"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31663-7"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.207"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(72)90082-4"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a128013"},{"key":"e_1_2_1_26_1","volume-title":"Anaerobe Laboratory Manual","author":"Holdeman LV","year":"1975"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/ajcn\/23.12.1608","article-title":"On the logarithmic transformation of intestinal bacterial counts","volume":"23","author":"Best WR","year":"1970","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_28_1","first-page":"14","article-title":"Les normes staturo\u2010pond\u00e9rales de l'enfant urbain canadien fran\u00e7ais d'\u00e2ge scolaire","volume":"63","author":"Demirjian A.","year":"1972","journal-title":"Can J Pub Health"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/ajcn\/25.6.576","article-title":"Triceps and subscapular skin\u2010fold thickness in French\u2010Canadian school\u2010age children in Montreal","volume":"25","author":"Jenicek M.","year":"1972","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/27.10.1052"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197311082891903"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1093\/ajcn\/32.12.2404","article-title":"The fecal microflora and bile acids in children with cystic fibrosis","volume":"32","author":"Roy CC","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0016-5085(79)90385-8","article-title":"National cooperative Crohn's disease study: results of drug treatment","volume":"77","author":"Summers RM","year":"1979","journal-title":"Gastroenterology"},{"key":"e_1_2_1_34_1","first-page":"311","volume-title":"Inflammatory bowel disease in children and adolescents. IN","author":"Hamilton JR","year":"1979"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.8.627"},{"key":"e_1_2_1_36_1","first-page":"63","volume-title":"Human growth and development","author":"McCammon RW","year":"1970"},{"key":"e_1_2_1_37_1","first-page":"1","volume-title":"The assessment of the nutritonal status of the community","author":"Jelliffe DB","year":"1966"},{"key":"e_1_2_1_38_1","first-page":"395","volume-title":"Total Parenteral Nutrition","author":"Bury KD","year":"1976"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0016-5085(19)32780-5","article-title":"Peripheral blood T and B cells in chronic inflammatory bowel disease","volume":"67","author":"Strickland RG","year":"1974","journal-title":"Gastroenterology"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5931.608"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(74)80527-5"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)32752-0"},{"key":"e_1_2_1_43_1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0016-5085(75)80232-0","article-title":"Structural and hormonal alterations in the gastrointestinal tract of parenterally fed rats","volume":"68","author":"Johnson LR","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308310"},{"key":"e_1_2_1_45_1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/ajcn\/23.5.546","article-title":"Studies in metabolic nutrition employing chemically defined diets. II. Effects on gut microflora populations","volume":"23","author":"Winitz M.","year":"1970","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.10.790"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.18.10.792"},{"key":"e_1_2_1_48_1","first-page":"979","article-title":"Bile acids regulate intestinal cell turnover","volume":"68","author":"Raicht RF","year":"1975","journal-title":"Gastroenterotogy"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-149-38943"},{"key":"e_1_2_1_50_1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0016-5085(75)80234-4","article-title":"Small intestinal mucosal injury in the experimental blind loop syndrome. Light and electronmicroscopic and histochemical studies","volume":"68","author":"Toskes PP","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_51_1","first-page":"355","article-title":"Influence of the normal flora on mucosal morphology and cellular renewal in the ileum","volume":"12","author":"Horams GD","year":"1963","journal-title":"Lab Invest"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607182006003194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:54:41Z","timestamp":1760630081000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607182006003194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1982,5]]}},"alternative-id":["10.1177\/0148607182006003194"],"URL":"https:\/\/doi.org\/10.1177\/0148607182006003194","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,5]]}}}