{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:04:42Z","timestamp":1787018682245,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1982,7,1]],"date-time":"1982-07-01T00:00:00Z","timestamp":394329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1982,7]]},"abstract":"<jats:p>The limitations of glucose\u2010based TPN solutions are high glucose concentration, high osmolality, lack of fat, and essential fatty acids, which result in glucose intolerance and hepatotoxic effects. We replaced one\u2010third of the calories in a standard amino acid\u2010glucose solution with Liposyn 10% for 14 days in 23 critically ill men who needed total parenteral nutrition. Serial measurements included weight, albumin, glucose, triglyceride concentrations, and liver function tests. Serum osmolality was calculated, and found to remain constant. Body weight and serum albumin were maintained. Minor changes occurred in hepatic enzymes which were physiologically insignificant. Glycosuria occurred in 15%. Adverse side effects of hypoglycemia, hyperosmolar coma, and hypertriglyceridemia were avoided. Our results show that the addition of fat reduced glucose and hepatic related metabolic complications.<\/jats:p>","DOI":"10.1177\/0148607182006004304","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"304-307","source":"Crossref","is-referenced-by-count":51,"title":["Reduced Metabolic Complications in Total Parenteral Nutrition: Pilot Study Using Fat to Replace One\u2010third of Glucose Calories"],"prefix":"10.1002","volume":"6","author":[{"given":"Michael M.","family":"Meguid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elihu","family":"Schimmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willard C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Meguid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Cohen","family":"Lowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bourinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Nabseth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1982,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197209000-00001"},{"key":"e_1_2_1_3_1","first-page":"573","article-title":"Serum hepatic enzyme and bilirubin elevations during parenteral nutrition","volume":"145","author":"Grant JP","year":"1977","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_4_1","first-page":"665","article-title":"Jr: Essential fatty acid deficiency associated with total parenteral nutrition","volume":"144","author":"Faulkner WJ","year":"1977","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860717700100101"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1978.01370160162028"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197404042901401"},{"key":"e_1_2_1_8_1","first-page":"168","volume-title":"Parenteral nutrition. IN Rhoads Textbook of Surgery. Principles and Practice","author":"Abbott WM","year":"1977"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0016-5085(76)80039-X","article-title":"Total parenteral nutrition at home: studies in patients surviving 4 months to 5 years","volume":"71","author":"Jeejeebhoy KN","year":"1976","journal-title":"Gastroenterology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197909000-00002"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198001000-00008"},{"key":"e_1_2_1_12_1","volume-title":"Amino Acids: Metabolism and Medical Application","author":"Landel A."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1974.01360060046013"},{"key":"e_1_2_1_14_1","first-page":"293","volume-title":"Regulation of fat metabolism in liver. IN Regulation in Metabolism","author":"Newsholme EA","year":"1973"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607182006004304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:40:31Z","timestamp":1760636431000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607182006004304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1982,7]]}},"alternative-id":["10.1177\/0148607182006004304"],"URL":"https:\/\/doi.org\/10.1177\/0148607182006004304","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7]]}}}