{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:52:57Z","timestamp":1760975577680,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1983,11,1]],"date-time":"1983-11-01T00:00:00Z","timestamp":436492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1983,11]]},"abstract":"<jats:p>Although hypocupremia is a well\u2010known consequence of long\u2010term total parenteral nutrition (TPN), its incidence as well as the duration of TPN necessary to induce it are still unsettled. The purpose of this study is to review the changes in serum copper level in 25 patients receiving TPN for a period longer than 2 wk (mean duration 6 wk) at the Istituto Nazionale Tumori of Milan and to evaluate the possible relationship of cupremia with the basic disease. Main indications for TPN included enterocutaneous fistulas (11 patients), cancer cachexia (10 patients), radiation enteropathy (two patients), and severe postoperative stricture following esophagogastric resection (two patients). Mean value of serum copper at the beginning of the study was 143 \u03bcg\/100 ml (normal value 65\u2013165 \u03bcg\/100 ml), and the regression analysis showed a mean fall of 5.64 \u03bcg\/100 ml\/wk. Hypocupremia occurred in four patients (three with intestinal fistulas and one with radiation obstructive enteritis) at 5th, 6th, 9th, and 6th wk of TPN. respectively. No patient with cancer cachexia developed hypocupremia. No patient with hypocupremia had clinical evidence of a copper deficiency syndrome. We conclude that <jats:italic>1<\/jats:italic>) hypocupremia does not occur within the first month of TPN; <jats:italic>2<\/jats:italic>) its incidence is about 16% in patients intravenously fed for period longer than 2 wk; <jats:italic>3<\/jats:italic>) it is more frequent in patients with enterocutaneous fistulas, whereas it never occurs in patients with cancer cachexia, and <jats:italic>4<\/jats:italic>) it is not necessarily associated to a clinicometabolic syndrome of copper deficiency. Finally, the \u201cnutritional\u201d meaning of serum copper should be questioned in cancer patients since it could represent a \u201ctumor marker.\u201d (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>7<\/jats:bold>:563\u2013566, 1983)<\/jats:p>","DOI":"10.1177\/0148607183007006563","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"563-566","source":"Crossref","is-referenced-by-count":11,"title":["Hypocupremia in Patients Receiving Total Parenteral Nutrition"],"prefix":"10.1002","volume":"7","author":[{"given":"Federico","family":"Bozzetti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Grazia Inglese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Terno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pupa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Sequeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Migliavacca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1983,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"51","article-title":"Determination of copper and iron","volume":"26","author":"Zak B.","year":"1960","journal-title":"Am J Med Technol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ajcn\/29.1.70","article-title":"A prospective study of serum copper and zinc levels in patients receiving total parenteral nutrition","volume":"29","author":"Fleming CR","year":"1976","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_4_1","first-page":"674","article-title":"Whole blood trace elements concentrations during total parenteral nutrition","volume":"79","author":"Hankins DA","year":"1976","journal-title":"Surgery"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197901000-00023"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0016-5085(76)80302-2","article-title":"Plasma trace metals during total parenteral nutrition","volume":"70","author":"Solomons NW","year":"1977","journal-title":"Gastroenterology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0016-5085(81)80060-1","article-title":"Copper metabolism and requirements in total parenteral nutrition","volume":"81","author":"Shike M.","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607180004006561"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"8444","DOI":"10.1016\/S0021-9258(17)34311-9","article-title":"A copper\u2010binding immunoglobulin from a myeloma patient","volume":"253","author":"Baker BL","year":"1978","journal-title":"J Biol Chem"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197607)38:1<244::AID-CNCR2820380136>3.0.CO;2-V"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1979.tb02796.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(69)80138-8"},{"key":"e_1_2_1_13_1","first-page":"325","article-title":"Value of fluctuations in the serum copper level in the control of patients with Hodgkin's disease","volume":"36","author":"Jelliffe AM","year":"1973","journal-title":"Nat Cancer Inst"},{"key":"e_1_2_1_14_1","first-page":"815","article-title":"Vijayvargiya R: Serum copper estimation in lymphomas","volume":"66","author":"Rawat M.","year":"1977","journal-title":"Indian J Med Res"},{"key":"e_1_2_1_15_1","first-page":"1337","article-title":"Serum copper observations in patients with malignant lymphoma","volume":"31","author":"Hrgovcic M.","year":"1973","journal-title":"Cancer"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197312)32:6<1512::AID-CNCR2820320631>3.0.CO;2-P"},{"key":"e_1_2_1_17_1","first-page":"411","article-title":"Feldman M: Serum copper alterations in genital cancer","volume":"21","author":"O'Leary JA","year":"1970","journal-title":"Surg Forum"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/030089167906500308","article-title":"Variations in serum copper and ceruloplasmin levels in advanced gastrointestinal cancer treated with polychemotherapy","volume":"65","author":"Scanni A.","year":"1979","journal-title":"Tumori"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000225249"},{"key":"e_1_2_1_20_1","first-page":"331","article-title":"Lorenzoni L: Serum copper in patients with uterine new growth with special reference to the cervical localization","volume":"86","author":"Vescovo R.","year":"1964","journal-title":"Ann Obstet Gynecol"},{"key":"e_1_2_1_21_1","first-page":"743","article-title":"Serum copper levels in lymphoma and leukemia\u2010special reference to Hodgkin's disease","volume":"24","author":"Hrygovcic M.","year":"1969","journal-title":"Cancer"},{"key":"e_1_2_1_22_1","first-page":"944","article-title":"Comportamento e significato prognostico della ceruloplasmina serica in relazione al quadro istopatologico della malattia di Hodgkin","volume":"59","author":"Pisi E.","year":"1968","journal-title":"Minerva Med"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1973.157"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718000400403"},{"key":"e_1_2_1_25_1","first-page":"1296","article-title":"Ceruloplasmin as a marker of neoplastic activity in rabbits bearing the VX\u20102 carcinoma","volume":"38","author":"Ungar\u2010Waron A.","year":"1978","journal-title":"Cancer Res"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(77)90056-1"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607183007006563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:05:59Z","timestamp":1760637959000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607183007006563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,11]]}},"alternative-id":["10.1177\/0148607183007006563"],"URL":"https:\/\/doi.org\/10.1177\/0148607183007006563","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1983,11]]}}}