{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:41:47Z","timestamp":1760640107419,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p>Parenteral nutrition (PN) is now an important facet of the management of the extremely premature infant. However, its effects on those with inherited metabolic disease have not been well documented. We report an infant with classical phenylketonuria (PKU) who had unusually high serum phenylalanine at 12 days of life (5200 \u03bcmol; &gt;3.2 SD above our mean for PKU at 10\u201315 days of age) while on parenteral nutrition, despite a relatively high tolerance for phenylalanine on oral feeds at 3\u20134 months of life (97\u2013128 mg\/ kg\/day; normal for PKU: &lt;90 mg\/kg\/day). Identification of PKU was somewhat delayed in this child because of failure to recognize that parenteral nutrition provides a phenylalanine load equivalent to or greater than the routine oral formula feeding. Despite the high levels of phenylalanine in the first 2 wk of life, mental and motor development are normal at 16 months of age. This case, the first such reported, suggests the parenteral nutrition in the premature PKU infant is relatively safe, but draws attention to the possible need for phenylalanine\u2010free amino acid infusates for those who require long\u2010term treatment. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>8<\/jats:bold>:42\u201344, 1984)<\/jats:p>","DOI":"10.1177\/014860718400800142","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"42-44","source":"Crossref","is-referenced-by-count":6,"title":["Parenteral Nutrition in a Premature Infant with Phenylketonuria"],"prefix":"10.1002","volume":"8","author":[{"given":"David E.C.","family":"Cole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Landry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80975-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198107000-00013"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.54.9.653"},{"key":"e_1_2_1_5_1","first-page":"29","article-title":"The natural food distribution center for management of patients with hereditary metabolic disease","volume":"6","author":"Clow CL","year":"1975","journal-title":"Bull Genet Soc Can"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1542\/peds.65.4.840","article-title":"Differential diagnosis of variant forms of hyperphenylalaninemia","volume":"65","author":"Kaufman S.","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90179-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(67)80022-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.14.120180.001143"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.10.6175"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(63)80131-6"},{"key":"e_1_2_1_12_1","first-page":"11","volume-title":"Phenylalaninemia: a study of the diversity of disorders which produce elevation of blood concentrations of phenylalanine. IN Amino Acid Metabolism and Genetic Variation","author":"Auerbach VH","year":"1969"},{"key":"e_1_2_1_13_1","first-page":"301","article-title":"The metabolism of phenylalanine and tyrosine in the premature infant","volume":"113","author":"Menkes JH","year":"1963","journal-title":"Bull Johns Hopkins Med School"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80693-8"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(74)90252-6"},{"key":"e_1_2_1_16_1","first-page":"75","volume-title":"Amino acid requirements and sources during total parenteral nutrition. IN Nutrition in Clinical Surgery","author":"Zlotkin SH","year":"1980"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860718400800142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:03:24Z","timestamp":1760637804000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860718400800142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1177\/014860718400800142"],"URL":"https:\/\/doi.org\/10.1177\/014860718400800142","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}