{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:10:59Z","timestamp":1761765059985,"version":"build-2065373602"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1984,5,1]],"date-time":"1984-05-01T00:00:00Z","timestamp":452217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:p>The relationship between serum transferrin (TFN) and serum total iron\u2010binding capacity (TIBC) in a clinical setting was evaluated in two related studies. The initial study evaluated 101 blood samples representing a cross\u2010section of hospitalized adults. The samples were double assayed for TIBC using clinical and research methodologies. TFN was assayed by a commercial radial immunodiffusion method. Clinical laboratory TIBC correlated well with research laboratory TIBC (r = 0.87, slope = 0.97, p &lt; 0.001, n = 50) and the relationship of TIBC to TFN yielded the following equation: TFN = 0.83 TIBC \u2014 5.6 (r = 0.82, p &lt; 0.001, n = 101) where TFN = mg\/100 ml and TIBC = <jats:italic>\u03bc<\/jats:italic> g\/100 ml. The second study evaluated a new TIBC assay and its effect on the TIBC\/TFN relationship. Additionally, the TFN\u2010TIBC relationship was evaluated at low normal and abnormal TIBC levels. In this second study, TFN = 1.0 TIBC \u2010 18.8 (r = 0.88, p &lt; 0.01, n = 126). Subsample analysis for specimens with TIBC between 105 and 160 showed a TIBC\u2010TFN regression line that was not significantly different than the entire sample. Inclusion of ancillary patient data such as hemoglobin and hematocrit did not improve the relationship between TFN and TIBC in either study. The relationship was unaffected by age, sex, race, disease, treatment, fever, surgery, degree of nutritional support, blood transfusion, or blood chemistry parameters in either study. Laboratories deriving TFN from measured TIBC as a nutritional status indicator must determine the relationship for the specific procedures being used in their laboratories. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>8:<\/jats:bold>274\u2013278, 1983)<\/jats:p>","DOI":"10.1177\/0148607184008003274","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"274-278","source":"Crossref","is-referenced-by-count":7,"title":["Relationships between Serum Total Iron\u2010Binding Capacity and Transferrin"],"prefix":"10.1002","volume":"8","author":[{"given":"Lon O.","family":"Crosby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Giandomenico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jameson","family":"Forster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Mullen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1984,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860717700100101"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260410023017"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1974.03240060028025"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1979.01370260011001"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800641217"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.3.429"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(80)90246-9"},{"key":"e_1_2_1_9_1","first-page":"276","article-title":"Correlation of mortality with serum transferrin and energy","volume":"1","author":"Kaminski MU","year":"1977","journal-title":"JPEN"},{"key":"e_1_2_1_10_1","first-page":"80","article-title":"Prediction of operative morbidity and mortality by preoperative nutritional assessment","volume":"30","author":"Mullen JL","year":"1979","journal-title":"Surg Forum"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90379-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5730.268"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1976.tb01178.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.43.230.459"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/9780470719923.ch12","volume-title":"Protein Turnover, CIBA Foundation Symposium. 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