{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:37:30Z","timestamp":1760888250865,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1985,3,1]],"date-time":"1985-03-01T00:00:00Z","timestamp":478483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1985,3]]},"abstract":"<jats:p>Intravenous fat emulsions (1, 2, and 3 g\/kg) were administered over 15 hr to 20 appropriate for gestational age premature infants with physiologic hyperbilirubinemia to determine the effect of fat infusions on the serum free fatty acid:albumin molar ratio (F\/A) and on unbound bilirubin. Significant increases (p &lt; 0.05) in F\/A occurred with each increase in lipid dose in infants &lt; 30 wk gestation, but not in infants \u2265 30 wk gestation. There was a direct linear correlation (r = 0.65, p &lt; 0.001) between F\/A ratio and unbound bilirubin (estimated fluorometrically by the ratio of albumin\u2010bound bilirubin\/reserve bilirubin binding capacity, B\/R). The largest increases in unbound bilirubin (albumin\u2010bound bilirubin\/reserve bilirubin binding capacity) were seen in infants with F\/ A &gt; 4.0. The gestational age of infants with F\/A &gt; 4.0 was significantly less (p &lt; 0.01) than infants with F\/A &lt; 4.0 (28.7 \u00b1 0.47 us. 31.1 \u00b1 0.40 wk, mean \u00b1 SEM). In 10\/58 infusions there was a fall in unbound bilirubin, unrelated to birthweight, gestational age, postnatal age, however, during these infusions the end\u2010infusion F\/A was \u2265 3.0. We conclude that 1 g\/kg of lipid emulsion infused over a 15\u2010hr period has minimal risk of decreasing bilirubin binding in premature infants &lt; 30 wk gestation. As doses of 2 or 3 g\/kg are used, these infants may be at risk of decreased bilirubin binding, due to elevations in the F\/A ratio. Monitoring of the F\/A ratio may identify infants at risk for decreased bilirubin binding during lipid infusion and provide guidelines for determining the appropriate lipid dose. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>9<\/jats:bold>:144\u2013147, 1985)<\/jats:p>","DOI":"10.1177\/0148607185009002144","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"144-147","source":"Crossref","is-referenced-by-count":34,"title":["The Effect of 15\u2010Hour Fat Infusions of Varying Dosage on Bilirubin Binding to Albumin"],"prefix":"10.1002","volume":"9","author":[{"given":"Michael L.","family":"Spear","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary E.","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary 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