{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:37:00Z","timestamp":1760888220767,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1985,7,1]],"date-time":"1985-07-01T00:00:00Z","timestamp":489024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:p>A series of studies was performed to test the efficacy and safety of a parenteral lipid emulsion, Lipofundin S, when given as part of a complete nutritive mixture from the three\u2010liter bag total parenteral nutrition (TPN) delivery system. In vitro stability studies with mixtures corresponding to high and low nutritional intakes showed the fat emulsion to be stable during refrigerated storage for at least 6 days. The clinical use of Lipofundin S in 3\u2010liter TPN bags was studied in 39 consecutive patients requiring TPN, and there were no untoward side\u2010effects. Nitrogen balance was maintained in patients with pancreatitis, those recovering postoperatively, and those with miscellaneous conditions. However, patients with multiple trauma remained in negative balance. The ability of sera, from patients on TPN to agglutinate Lipofundin S was compared to that from healthy controls, and acutely ill patients not on TPN. Patients on TPN showed a higher degree of in vitro creaming than acutely ill controls, and this may have been related to the severity of the underlying illness. These studies suggest that this parenteral lipid emulsion can be safely administered to patients requiring TPN when given from the 3\u2010liter bag delivery system. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>9<\/jats:bold>:456\u2013460, 1985)<\/jats:p>","DOI":"10.1177\/0148607185009004456","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"456-460","source":"Crossref","is-referenced-by-count":15,"title":["Administration of Fat Emulsions with Nutritional Mixtures from the 3\u2010Liter Delivery System in Total Parenteral Nutrition"],"prefix":"10.1002","volume":"9","author":[{"given":"G.K.","family":"Grimble","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.H.","family":"Patil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.P.","family":"Keohane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.A.","family":"Attrill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.G.","family":"Frost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Cribb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.B.A.","family":"Silk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197606242942601"},{"key":"e_1_2_1_3_1","first-page":"423","article-title":"Nitrogen sparing effect of fat emulsions, compared with glucose in the post\u2010operative patient","volume":"142","author":"Bark S.","year":"1976","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197704000-00008"},{"key":"e_1_2_1_5_1","first-page":"103","article-title":"Glucose or fat as a non\u2010protein energy source? A controlled clinical trial in gastroenterological patients requiring intravenous nutrition","volume":"80","author":"MacFie J.","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90061-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198001000-00008"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197909000-00002"},{"volume-title":"Nutritional Support in Hospital Practice","year":"1983","author":"Silk DBA","key":"e_1_2_1_9_1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92601-6"},{"key":"e_1_2_1_11_1","first-page":"674","article-title":"Parenteral nutrition","volume":"1","author":"Jones BJM","year":"1982","journal-title":"Med Int"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/ajcn\/16.1.129","article-title":"Flocculation of intravenous fat emulsions","volume":"16","author":"Le Veen HH","year":"1965","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_13_1","first-page":"27","volume-title":"Total Parenteral Nutrition","author":"Giovanoni R.","year":"1976"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-7188-5_10"},{"key":"e_1_2_1_15_1","first-page":"151","article-title":"Complete nutrient mixtures with lipids for total parenteral nutrition in cancer patients","volume":"478","author":"Solassol CL","year":"1980","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_16_1","first-page":"99","article-title":"Parenterale Ernahrung bei Schwerer Leberinsuffizienz","volume":"16","author":"Kleinberger G.","year":"1980","journal-title":"Z Gastroenterol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1980.01380070077023"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6113.625"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90922-4"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.51.597.441"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91328-9"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-5918-0_19"},{"key":"e_1_2_1_23_1","first-page":"86","article-title":"Morphologic changes of Intralipid 29% liposomes in all\u2010in\u2010one solutions during prolonged storage","volume":"9","author":"Pamperl H.","year":"1982","journal-title":"Infusionstherapie"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-5918-0_20"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607185009004456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:31:04Z","timestamp":1760635864000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607185009004456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1177\/0148607185009004456"],"URL":"https:\/\/doi.org\/10.1177\/0148607185009004456","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}