{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:00:26Z","timestamp":1770505226438,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1985,7,1]],"date-time":"1985-07-01T00:00:00Z","timestamp":489024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:p>Abnormal serum liver enzymes are common in adults receiving total parenteral nutrition (TPN). The mechanism(s) responsible for these changes is unclear. One hypothesis is that there is overgrowth of intestinal anaerobic bacteria with subsequent toxic effects on the liver from endotoxins and\/ or bile acids. A retrospective survey of patients receiving TPN was undertaken. The patients were divided into two matched groups. One group had received metronidazole, a drug that suppresses anaerobic bacteria, while the other group had not. The administration of metronidazole during TPN was associated with prevention of the expected rise of serum alkaline phosphatase, \u03b3 glutamyl transpeptidase, and aspartate aminotransferase. This study supports the concept that anerobic intestinal bacteria may be involved in the pathogenesis of liver changes commonly observed during TPN. (Journal of Parenteral and Enteral Nutrition 9:501\u2013503, 1985)<\/jats:p>","DOI":"10.1177\/0148607185009004501","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"501-503","source":"Crossref","is-referenced-by-count":54,"title":["Metronidazole Prevention of Serum Liver Enzyme Abnormalities during Total Parenteral Nutrition"],"prefix":"10.1002","volume":"9","author":[{"given":"John R.","family":"Lambert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/76.3.276"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1001\/jama.1979.03290480032019","article-title":"Liver function values in adults receiving total parenteral nutrition","volume":"241","author":"Lindor KD","year":"1979","journal-title":"JAMA"},{"key":"e_1_2_1_4_1","first-page":"540","volume-title":"New Aspects of Clinical Nutrition","author":"Sitges\u2010Serra A.","year":"1983"},{"key":"e_1_2_1_5_1","first-page":"641","article-title":"Cholestasis caused by lipid emulsions","volume":"154","author":"Allardyce DB","year":"1982","journal-title":"Surg Gynaecol Obstet"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0016-5085(82)80258-8","article-title":"Hepatic alterations during total parenteral nutrition in patients with inflammatory bowel disease: a possible consequence of lithocholate toxicity","volume":"82","author":"Fouin\u2010Fortunet H.","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0016-5085(19)32333-9","article-title":"The role of endotoxin in liver injury","volume":"69","author":"Nolan JP","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archinte.1972.03650040130012","article-title":"Bile acids, liver injury and liver disease","volume":"130","author":"Palmer RH","year":"1972","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198011203032106"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.14.4.636"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0016-5085(73)80088-5","article-title":"Patterns of bile acids and microflora in the human small intestine. (1) Bile acids, (2) Microflora","volume":"64","author":"Mallory A.","year":"1973","journal-title":"Gastroenterology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0016-5085(76)80018-2","article-title":"Cholestatic effects of Escherichia coli endotoxin on the isolated perfused rat liver","volume":"70","author":"Utili R.","year":"1976","journal-title":"Gastroenterology"},{"key":"e_1_2_1_13_1","volume-title":"A model of TPN related hepato\u2010biliary dysfunction in the young pig","author":"Truskett P."},{"key":"e_1_2_1_14_1","first-page":"A996","article-title":"Effect of water on bile excretion in guinea pigs receiving total parenteral nutrition","volume":"24","author":"La Brooy SJ","year":"1983","journal-title":"Gut"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91442-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92888-X"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0016-5085(82)80403-4","article-title":"Hepatic steatosis after intestinal bypass. Prevention and reversal by metronidazole, irrespective of protein\u2010caloric malnutrition","volume":"82","author":"Drenick EJ","year":"1982","journal-title":"Gastroenterology"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607185009004501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:30:40Z","timestamp":1760635840000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607185009004501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1177\/0148607185009004501"],"URL":"https:\/\/doi.org\/10.1177\/0148607185009004501","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}