{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:32:31Z","timestamp":1782826351369,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1985,9,1]],"date-time":"1985-09-01T00:00:00Z","timestamp":494380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p>Patients with moderate to severe alcoholic hepatitis and features of protein\u2010calorie malnutrition were studied with respect to changes in their nutritional status during 30 days of hospitalization. Thirty\u2010four patients served as controls, were given a 2500 kcal hospital diet and allowed to eat ad libitum. Twenty\u2010three patients were given, in addition to the hospital diet, a nutrition supplement high in calories, protein, and branched\u2010chain amino acids (Hepatic Aid). Because of anorexia, the controls consumed lesser amounts of both calories and protein while those given the nutritional therapy exceeded their estimated energy requirements (116.1 %) and consumed a mean of 98.3 g of protein per day. This was well tolerated despite the fact that portal systemic encephalopathy was present in 72% of the patients. Mortality associated with the liver disease was comparable in both groups, 16.7% in the treated us 20.6% in the controls. In those patients that survived the 30 days of hospitalization, clinical and biochemical tests of liver injury improved in both groups. With respect to their nutritional status, those given nutritional therapy showed significant improvement in six of the nine parameters (67%) used to assess nutrition. In the controls significant improvement was observed in only two nutritional parameters (22%) while three parameters (33%) deteriorated further. These three were all associated with calorie deprivation (marasmus). This study suggests that patients with acute alcoholic hepatitis require additional nutritional therapy to maintain and improve their nutrition parameters, especially those related to marasmus; and that Hepatic Aid is well tolerated for this purpose. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>9<\/jats:bold>:590\u2013596, 1985)<\/jats:p>","DOI":"10.1177\/0148607185009005590","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"590-596","source":"Crossref","is-referenced-by-count":112,"title":["VA Cooperative Study on Alcoholic Hepatitis III: Changes in Protein\u2010Calorie Malnutrition Associated with 30 Days of Hospitalization with and without Enteral Nutritional Therapy"],"prefix":"10.1002","volume":"9","author":[{"given":"C.","family":"Mendenhall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Bongiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rouster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tamburro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Weesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"VA COOPERATIVE STUDY GROUP ON ALCOHOLIC HEPATITIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1985,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31653-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/ajcn\/32.6.1304","article-title":"Alcohol, malnutrition, and alcoholic cirrhosis","volume":"32","author":"Patek AJ Jr","year":"1979","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/ajcn\/16.4.339","article-title":"B\u2010complex vitamins in liver disease of the alcoholic","volume":"16","author":"Leevy CM","year":"1965","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-197112000-00007"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193310000-00013"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-193503000-00011"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcn\/23.4.493","article-title":"Vitamins and liver injury","volume":"23","author":"Leevy CM","year":"1970","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1041751"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archinte.1975.00330080055008","article-title":"Alcohol and dietary factors in cirrhosis: an epidemiological study of 304 alcoholic patients","volume":"135","author":"Patek AJ Jr","year":"1975","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_11_1","first-page":"91","volume-title":"Problems in Liver Diseases","author":"Halsted CH","year":"1979"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90776-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412063112302"},{"key":"e_1_2_1_14_1","first-page":"76","volume-title":"Diseases of the liver and biliary tract. 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