{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:19:12Z","timestamp":1774261152223,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1985,11,1]],"date-time":"1985-11-01T00:00:00Z","timestamp":499651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p>We report a case of biotin deficiency developed in a 25\u2010yr\u2010old man with Crohn's disease who had been on total parenteral nutrition for more than 9 months. His cutaneous, ophthalmic, and neurologic manifestations were characteristic of this disease entity described in literature. In particular, the appearance of his face deserves to be called \u201cbiotin deficiency facies.\u201d After administration of biotin the low plasma nonesterified fatty acid level promptly returned to normal. This phenomenon may prove to serve as a convenient means for the purpose of detecting biotin deficiency. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>9:<\/jats:bold>760\u2013763, 1985)<\/jats:p>","DOI":"10.1177\/0148607185009006760","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"760-763","source":"Crossref","is-referenced-by-count":21,"title":["Biotin Deficiency during Total Parenteral Nutrition: Its Clinical Manifestation and Plasma Nonesterified Fatty Acid Level"],"prefix":"10.1002","volume":"9","author":[{"given":"Satoru","family":"Matsusue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadao","family":"Kashihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunzo","family":"Koizumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,11]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"381","volume-title":"Vitamins in Medicine","author":"Mistry SP","year":"1980"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198104023041404"},{"key":"e_1_2_1_4_1","first-page":"141","article-title":"A skin lesion associated with biotin deficiency state during long term total parenteral nutrition","volume":"80","author":"Mashima Y.","year":"1979","journal-title":"J Jpn Surg Soc"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198104023041405"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1001\/jama.1982.03320470062035","article-title":"Biotin deficiency in an adult during home parenteral nutrition","volume":"247","author":"McClain CT","year":"1982","journal-title":"JAMA"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607182006004308"},{"key":"e_1_2_1_8_1","first-page":"589","article-title":"Biotin deficiency in a patient with short bowel syndrome during home parenteral nutrition","volume":"6","author":"Khalidi N.","year":"1982","journal-title":"JPEN"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607183007002181"},{"key":"e_1_2_1_10_1","first-page":"107","article-title":"Biotin in man's nutrition and therapy: a review","volume":"47","author":"Bonjour JP","year":"1977","journal-title":"Int J Vit Nutr Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1942.02830140029009"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197604000-00001"},{"key":"e_1_2_1_13_1","first-page":"583","volume-title":"The biosynthesis of lipids. 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