{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:12:35Z","timestamp":1766362355762,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>We have previously shown that supplemental vitamin E has a cytoprotective effect in the liver of rats with chronic CCL<jats:sub>4<\/jats:sub>\u2010induced liver cirrhosis. In this study, we hypothesized that vitamin E would have a protective effect in acute liver injury induced by D\u2010galactosamine. D\u2010Galactosamine\u2010induced injury has been thought to be due to a synergistic direct toxic effect and presence of intestinal bacteria and\/or endotoxins. D\u2010Galactosamine was used to induce acute \u201chepatitis\u201d (1.5\u20132.0 g\/Kg body weight, ip). Rats were placed on either standard chow or the same chow supplemented with vitamin E (300 mg DL\u2010alpha\u2010tocopherol\/Kg diet) and 6 days later were given D\u2010galactosamine. There was significantly improved early (5\u2010day) survival and late (14\u2010day) survival in the vitamin E\u2010supplemented group. The vitamin E beneficial effect was manifested also by decreased liver fat and collagen content and decreased SGPT level. Because bacterial endotoxins have been implicated as playing a role in the pathogenesis of D\u2010galactosamine hepatitis, the same experiment was carried out using germ\u2010free and conventional rats. There was significantly improved survival in both the germ\u2010free and conventional vitamin E\u2010supplemented groups both at 5 and 14 days. There was no significant difference between conventional and germ\u2010free rats with or without vitamin E supplementation. In summary (a) vitamin E improves the early fat and collagen accumulation in the liver, decreases SGPT level, and improves survival in the D\u2010galactosamine experimental model of acute liver injury in both conventional and germ\u2010free rats; and (b) D\u2010galactosamine toxicity is probably not mediated through intestinal bacteria and\/or endotoxins. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> 10:184\u2013187,1986)<\/jats:p>","DOI":"10.1177\/0148607186010002184","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"184-187","source":"Crossref","is-referenced-by-count":12,"title":["Protective Effect of Vitamin E in Rats with Acute Liver Injury"],"prefix":"10.1002","volume":"10","author":[{"given":"Lisa","family":"Sclafani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Shimm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Edelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Seifter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley M.","family":"Levenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achilles A.","family":"Demetriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(70)90050-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00215578"},{"key":"e_1_2_1_4_1","first-page":"237","article-title":"Biochemical pathology of liver cell necrosis","volume":"81","author":"Farber J.","year":"1975","journal-title":"Am J Pathol"},{"key":"e_1_2_1_5_1","first-page":"1516","article-title":"D\u2010galactosamine and acute liver cell injury","volume":"32","author":"Shinozuka H.","year":"1973","journal-title":"Fed Proc"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(82)90161-1"},{"key":"e_1_2_1_7_1","first-page":"25","article-title":"Galactosamine\u2010induced cell death in primary cultures of rat hepatocytes","volume":"100","author":"Schanne F.","year":"1980","journal-title":"Am J Pathol"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31230.x"},{"volume-title":"Vitamin E given prophylactically partially inhibits accumulation of liver collagen","author":"Seifter E. Rettura J.","key":"e_1_2_1_9_1"},{"volume-title":"Protective effect of vitamin E in cirrhotic rats following partial hepatectomy","author":"Demetriou AA","key":"e_1_2_1_10_1"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-172-41555"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF02889560","article-title":"On the pathogenesis of galactosamine hepatitis","volume":"26","author":"Liehr H.","year":"1978","journal-title":"Virchows Arch [Cell Pathol]"},{"key":"e_1_2_1_13_1","first-page":"356","article-title":"Lactulose\u2010a drug with anti\u2010endotoxin effect","volume":"27","author":"Liehr H.","year":"1980","journal-title":"Acta Hepato Gastroenterol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/jn\/97.4.542","article-title":"Influence of microorganisms on oxygen consumption, carbon dioxide production, and colonic temperature","volume":"97","author":"Levenson SM","year":"1969","journal-title":"J Nutr"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0021-9258(18)55987-1","article-title":"Preparation of lipid extract from brain tissue","volume":"191","author":"Folch J.","year":"1956","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(61)90291-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/28.1.56"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0022-2275(20)38099-8","article-title":"Alterations in lipoprotein composition associated with galactosamine\u2010induced rat liver injury","volume":"23","author":"Cartwright CK","year":"1982","journal-title":"J Lipid Res"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(82)90102-0"},{"key":"e_1_2_1_20_1","first-page":"578","article-title":"Hepatocellular transplantation for treatment of D\u2010galactosamine\u2010induced acute liver failure in rats","volume":"11","author":"Sommer BG","year":"1979","journal-title":"Transplantation"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31252.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31250.x"},{"key":"e_1_2_1_23_1","first-page":"321","article-title":"Protective role of hydrocortisone on galactosamine\u2010induced hepatitis into rats","volume":"69","author":"Bartsokas S.","year":"1977","journal-title":"Endocrinologie"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840030217"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(80)90060-X"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607186010002184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:48:49Z","timestamp":1760633329000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607186010002184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1177\/0148607186010002184"],"URL":"https:\/\/doi.org\/10.1177\/0148607186010002184","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}