{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:30:07Z","timestamp":1760661007425,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>Zinc deficiency is well known to alter immunity. We report the case of a 18\u2010yr\u2010old female with relapsing Crohn's disease who experienced acrodermatitis enteropathica due to zinc deficiency during total parenteral nutrition (TPN). Blood lymphocytes have been studied by flow cytometry: before zinc treatment an important decrease of T\u2010helper lymphocytes with high level of OKM\u20105 + lymphocytes had been observed. Zinc\u2010supplemented diet induced within a few days, a rise of T\u2010helper lymphocytes and a proportional reduction of OKM5 + cells. Increased values of high metabolism surface marker (OKT\u20109) were also observed, as well as cytoplasmic modifications. The authors suggest that lymphocyte surface markers could be useful to monitor TPN in patients at high risk for zinc deficiency. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> 10:239\u2013241, 1986)<\/jats:p>","DOI":"10.1177\/0148607186010002239","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"239-241","source":"Crossref","is-referenced-by-count":7,"title":["Zinc Deficiency and Lymphocyte Subpopulations. A Study by Flow Cytometry"],"prefix":"10.1002","volume":"10","author":[{"given":"Yves","family":"Couvreur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Paul","family":"Quarre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Cornut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,3]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2","article-title":"Trace Elements","volume":"1","author":"Prasad AS","year":"1976","journal-title":"Human Health and Disease"},{"key":"e_1_2_1_3_1","first-page":"408","volume-title":"Modern Nutrition in Health and Disease","author":"Li TK","year":"1980"},{"key":"e_1_2_1_4_1","first-page":"605","article-title":"Zinc deficiency and intravenous feeding","volume":"2","author":"Kay RG","year":"1975","journal-title":"Lancet"},{"key":"e_1_2_1_5_1","first-page":"331","article-title":"A syndrome of acute zinc deficiency during total parenteral alimentation in man","volume":"4","author":"Kay RG","year":"1976","journal-title":"Ann Surg"},{"key":"e_1_2_1_6_1","first-page":"5","article-title":"Home parenteral nutrition: Results in 34 pediatric patients","volume":"13","author":"Strobel CT","year":"1978","journal-title":"Ann Surg"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80198-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(81)80671-9"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92463-7"},{"key":"e_1_2_1_10_1","first-page":"141","article-title":"Treatment of a child with severe combined immunodeficiency with zinc and thymopoietin pentapeptide (TP\u20105)","volume":"2","author":"Fiorilli M.","year":"1982","journal-title":"Immunol Clin Sper"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607186010002239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:49:10Z","timestamp":1760633350000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607186010002239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1177\/0148607186010002239"],"URL":"https:\/\/doi.org\/10.1177\/0148607186010002239","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}