{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:50:07Z","timestamp":1760885407510,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1986,5,1]],"date-time":"1986-05-01T00:00:00Z","timestamp":515289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p>The efficacy and safety of short\u2010term supplemental peripheral hyperalimentation (PH) was evaluated in 15 hospitalized cystic fibrosis (CF) patients who exhibited varying degrees of pulmonary disease severity and nutritional impairment. An average of 1000 supplemental calories\/day were administered intravenously for a 2\u2010 to 3\u2010week period to patients being treated with parenteral antibiotics for exacerbation of their pulmonary disease. Eleven of 15 patients responded with a weight gain of &gt; 2.0 kg and showed continued weight gain and stabilized pulmonary status for the 6\u2010 to 12\u2010month follow\u2010up period; two patients showed dramatic reversal of poor weight gain and growth following PH. Total calorie intake (oral + PH) equaled 141 \u00b1 40% of the recommended dietary allowances (RDA) in responders, with 45 \u00b1 12% RDA contributed by PH, in contrast to 68 \u00b1 20% of the RDA for total calories with 31 \u00b1 13% supplied using PH achieved in the nonresponders. Linoleic acid deficiency was documented in these patients (linoleic acid level as a percent of total fatty acid = 21.9% \u00b1 1.41 SEM <jats:italic>vs<\/jats:italic> 31.8% \u00b1 1.16 SEM in normal controls), and all seven patients achieved normalization of linoleic acid level after PH. Prior assessment of nutritional status (anthropometric measurements) or of severity of pulmonary disease (NIH clinical score) did not allow prediction of response to PH. No complications resulted from administration of PH to these hospitalized CF patients. 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