{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:15:10Z","timestamp":1771078510334,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1986,9,1]],"date-time":"1986-09-01T00:00:00Z","timestamp":525916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:p>The effects of alternate and simultaneous administrations of calcium (Ca) and phosphorus (P) on Ca metabolism in children receiving total parenteral nutrition (TPN) were examined. Eight children, aged 2 to 36 months, were studied. The following three solutions were administered: solution 1 contains Ca (533 mg\/liter); solution 2 contains P (413 mg\/liter); and solution 3 contains Ca (267 mg\/liter) and P (207 mg\/liter). Solutions 1 and 2 were administered alternately for 24\u2010hr periods. (Results) I. During administration of solution 1, significant hypophosphatemia (4.39 \u00b1 0.26 mg\/dl) and hypercalcemia (9.96 \u00b1 0.15 mg\/dl) were observed and, conversly, during administration of solution 2, significant hypocalcemia (8.36 \u00b1 0.18 mg\/dl) and hyperphosphatemia (6.16 \u00b1 0.27 mg\/ dl) were observed. During administration of solution 3, the serum levels of both minerals were maintained within the normal ranges (Ca 9.46 \u00b1 0.12 mg\/dl, P 5.65 \u00b1 0.21 mg\/dl). II. The urinary excretion of cyclic AMP was significantly lower during administration of solution 1 (6.67 \u00b1 0.45 nmol\/mg creatinine (Cr)) as compared with solution 3 (7.50 \u00b1 0.61 nmol\/ mg of Cr). On the other hand, the excretion was significantly higher during administration of solution 2 (11.55 \u00b1 1.58 nmol\/ mg of Cr) as compared with solution 3, indicating the existence of secondary hyperparathyroidism. III. The Ca and Pretention rates were significantly higher with solution 3 (Ca 79.0 \u00b1 5.5%, P 73.2 \u00b1 7.2% of the intake) than with solutions 1 and 2 alternately (Ca 62.7 \u00b1 4.5%, P 49.2 \u00b1 9.3%). (Conclusions) Simultaneous administrations of Ca and P are preferable to their alternate administrations for Ca metabolism in children receiving TPN. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>10:<\/jats:bold> 513\u2013516,1986)<\/jats:p>","DOI":"10.1177\/0148607186010005513","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"513-516","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Alternate and Simultaneous Administrations of Calcium and Phosphorus on Calcium Metabolism in Children Receiving Total Parenteral Nutrition"],"prefix":"10.1002","volume":"10","author":[{"given":"Saburo","family":"Kimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Seino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuzo","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinobu","family":"Kanaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyakuji","family":"Yabuuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Itakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-3-343"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92271-0"},{"key":"e_1_2_1_4_1","first-page":"74","article-title":"Infantile 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