{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:49:57Z","timestamp":1760982597133,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1986,9,1]],"date-time":"1986-09-01T00:00:00Z","timestamp":525916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:p>Copper (Cu) deficiency has been reported both in pediatric and adult patients on total parenteral nutrition (TPN). Manifestations of Cu deficiency are usually hematologic in the adult. A 56\u2010yr\u2010old patient with a history of subtotal gastrectomy underwent massive small bowel resection and partial colectomy in 1977. TPN was initiated. Intravenous (iv) trace mineral supplements were not available in 1977 at our institution. By June 1978, the patient manifested neutropenia with a white blood cell (WBC) count of 2000\/mm<jats:sup>3<\/jats:sup> and 39% neutrophils or a total neutrophil count (TNC) of 780\/mm<jats:sup>3<\/jats:sup>. The serum Cu level at that time was 5 \u03bcg\/dl (normal, 70\u2013140), and the serum zinc (Zn) level was low, although within normal limits. Oral supplementation with Cu and Zn tablets proved ineffective. Twice weekly infusions of fresh frozen plasma were begun in April 1979, and intravenous chromium supplementation started in September 1979, but neither the WBC count nor the TNC improved. Intravenous Cu and Zn were approved in October 1979, and were added to the TPN formula. Within 2 weeks, the WBC count rose to 6300\/mm<jats:sup>3<\/jats:sup>, and the neutrophils increased to 83% with a TNC of 5229. After 12 weeks, the serum Cu level rose to 80 \u03bcg\/dl The increase in WBC count and percentage of neutrophils can be attributed to the addition of Cu to the TPN infusate. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>10:<\/jats:bold> 530\u2013532, 1986)<\/jats:p>","DOI":"10.1177\/0148607186010005530","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"530-532","source":"Crossref","is-referenced-by-count":21,"title":["Neutropenia Due to Copper Deficiency in Total Parenteral Nutrition"],"prefix":"10.1002","volume":"10","author":[{"given":"Krishnan","family":"Sriram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"O'Gara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Strunk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie K.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1986,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1985.10720069"},{"key":"e_1_2_1_3_1","first-page":"764","article-title":"A sex\u2010linked recessive disorder with retardation of growth, peculiar hair, and focal cerebral and cerebellar degeneration","volume":"29","author":"Menkes JH","year":"1962","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80449-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1001\/jama.1979.03290450049024","article-title":"Department of Foods and Nutrition. Guidelines for essential trace element preparations for parenteral use","volume":"241","author":"American Medical Association","year":"1979","journal-title":"JAMA"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0016-5085(81)80060-1","article-title":"Copper metabolism and requirements in total parenteral nutrition","volume":"81","author":"Shike M.","year":"1981","journal-title":"Gastroenterology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ajcn\/29.1.70","article-title":"A prospective study of serum copper and zinc levels in patients receiving parenteral nutrition","volume":"29","author":"Flemming CR","year":"1976","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830030209"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/ajcn\/35.3.542","article-title":"Urinary copper losses in infants receiving free amino acids solutions","volume":"35","author":"Tyrala EE","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1001\/jama.1978.03290200044019","article-title":"Hypocupremia induced by zinc therapy in adults","volume":"240","author":"Prasad AS","year":"1978","journal-title":"JAMA"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/0016-5085(78)90239-1","article-title":"Incorporation of radiocopper into ceruloplasmin in normal subjects and in patients with primary biliary cirrhosis and Wilson's disease","volume":"74","author":"Vierling JM","year":"1978","journal-title":"Gastroenterology"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S0016-5085(77)80016-4","article-title":"Biliary secretion of copper in healthy man: Quantitation by an intestinal perfusion technique","volume":"72","author":"Van Berge Henegouwen GP","year":"1977","journal-title":"Gastroenterology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1152\/physrev.1935.15.3.471","article-title":"The biological significance of copper and its relation to iron metabolism","volume":"15","author":"Elvehjem CA","year":"1935","journal-title":"Physiol Rev"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1542\/peds.34.3.324","article-title":"Copper deficiency in infancy","volume":"34","author":"Cordano A.","year":"1964","journal-title":"Pediatrics"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103201"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)31864-8"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607186010005530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:55:23Z","timestamp":1760637323000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607186010005530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1986,9]]}},"alternative-id":["10.1177\/0148607186010005530"],"URL":"https:\/\/doi.org\/10.1177\/0148607186010005530","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1986,9]]}}}