{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:09:57Z","timestamp":1785884997338,"version":"3.56.0"},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p>Broviac catheters are commonly used to provide parenteral nutrition and access for infusion of blood products and drugs to pediatric patients. Sepsis is the most common serious complication of continued catheter use. Although removal of the catheter is generally recommended when it becomes contaminated, it may not be feasible to do so without compromising patient care. We evaluated the management of catheter\u2010related infections in pediatric patients with and without removal of catheter. Seventy\u2010seven episodes of catheter sepsis were evaluated in 61 pediatric patients; 24 were neonates and 37 were older children. The catheters were used for multiple purposes in 75% of cases. The most common microorganisms isolated were <jats:italic>Staphylococcus epidermidis<\/jats:italic> in 26%, <jats:italic>Klebsiella pneumoniae<\/jats:italic> in 9%, and <jats:italic>Streptococcus viridans<\/jats:italic> in 8% of cases; other pathogens included group D Enterococcus, <jats:italic>Staphylococcus aureus,<\/jats:italic> and <jats:italic>Escherichia coli. Pseudomonas aeruginosa<\/jats:italic> was isolated in four older children. Thirty\u2010five patients were treated with antibiotics without catheter removal. Thirty patients received appropriate antibiotic therapy based on the susceptibility data. Twenty\u2010six of these 30 patients responded within 5 days of therapy whereas the others required 15\u201339 days of treatment. Lack of response was mainly associated with the presence of abscess, immunocompromised status, and organisms P. <jats:italic>aeruginosa<\/jats:italic> and <jats:italic>Candida albicans.<\/jats:italic> Based on the sensitivity and minimum inhibitory concentration data, a combined regimen of gentamicin and vancomycin would be an effective initial therapy. These findings suggest that (1) catheter sepsis can be managed with appropriate antibiotics, and (2) when continued use of Broviac catheter is desired, a trial of antibiotic therapy should be attempted before catheter removal. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>12:<\/jats:bold>58\u201359, 1988)<\/jats:p>","DOI":"10.1177\/014860718801200158","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"58-59","source":"Crossref","is-referenced-by-count":42,"title":["Management of Catheter\u2010Related Infections in Pediatric Patients"],"prefix":"10.1002","volume":"12","author":[{"given":"Milap C.","family":"Nahata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis R.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight A.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Marx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Ginn\u2010Pease","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1988,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-79-6-867"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80034-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198601000-00004"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-198403000-00005"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860718801200158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:41:53Z","timestamp":1760640113000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860718801200158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1177\/014860718801200158"],"URL":"https:\/\/doi.org\/10.1177\/014860718801200158","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}