{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:09:57Z","timestamp":1785884997620,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:p>Frequent guidewire changes of single\u2010lumen (SLC) and triple\u2010lumen (TLC) catheters have been proposed to decrease catheter sepsis. We placed TLC in 126 patients needing total parenteral nutrition (TPN) and multiple venous access, prospectively randomizing them to two groups: group I received a guidewire change every 3 days, and group II received guidewire changes for mechanical or septic complications only. Tips were cultured at each line change and tips and blood for each septic episode. Catheter sepsis was defined by the criteria of the Association for Practitioners in Infection Control (APIC). There were 67 positive cultures in 52 patients, but most produced very few colonies or grew the same organisms in other infection sites. Forty\u2010seven% of all cultures grew <jats:italic>Staphylococci,<\/jats:italic> and 23% grew <jats:italic>Candida.<\/jats:italic> APIC\u2010defined catheter sepsis was detected in 12.7% of group I and 15.9% of group II. Although we observed no statistically significant difference in the two techniques, if we assume that a 20% difference in the incidence of catheter\u2010induced sepsis would be important to detect, the probability of failing to detect such a difference is 0.24 with an 0.05 level of significance (two\u2010sided). Prophylactic guidewire changes did not alter the incidence of catheter sepsis in patients with TLC who required TPN. The high rate of sepsis and <jats:italic>Candida<\/jats:italic> infection may be due to the critical illness of the immunocompromised population studied. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>12:<\/jats:bold>462\u2013464, 1988)<\/jats:p>","DOI":"10.1177\/0148607188012005462","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"462-464","source":"Crossref","is-referenced-by-count":42,"title":["Effect of Frequent Guidewire Changes on Triple\u2010Lumen Catheter Sepsis"],"prefix":"10.1002","volume":"12","author":[{"given":"Carla","family":"Powell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Kudsk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Kulich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A.","family":"Mandelbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Fabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1988,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198408000-00005"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197404042901401"},{"key":"e_1_2_1_4_1","first-page":"577","article-title":"Intravenous hyperalimentation without sepsis","volume":"136","author":"Sanderson I.","year":"1973","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010005487"},{"key":"e_1_2_1_6_1","first-page":"14","article-title":"Sepsis due to triple lumen central venous catheters","volume":"163","author":"Kelly CS","year":"1986","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1986.01400050109014"},{"key":"e_1_2_1_8_1","first-page":"102","article-title":"Bacteremia outbreak limited to use of multilumen catheters","author":"Pfeiffer J.","year":"1986","journal-title":"Hosp Infect Cont"},{"key":"e_1_2_1_9_1","volume-title":"Sepsis related to multilumen intravascular catheters: A challenge for the infection control practitioner","author":"Hoover P."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198307000-00009"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90153-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607188012002127"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607188012005462","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607188012005462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T14:10:39Z","timestamp":1760623839000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607188012005462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1177\/0148607188012005462"],"URL":"https:\/\/doi.org\/10.1177\/0148607188012005462","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]}}}