{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:06:16Z","timestamp":1779887176974,"version":"3.53.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1989,3,1]],"date-time":"1989-03-01T00:00:00Z","timestamp":604713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:p>D\u2010lactate accumulates in some patients with malabsorption who continue oral intake of carbohydrate leading to a clinical syndrome of acidosis and encephalopathy. To assess the possibility that D\u2010lactate contributes to acidosis and\/ or metabolic bone disease in patients with malabsorption receiving long\u2010term parenteral nutrition yet maintaining oral intake, D\u2010lactate levels in serum and urine were measured in 14 long\u2010term parenteral nutrition subjects (average duration of support 74 months) and 27 control subjects. Significant elevations in both serum and urine D\u2010lactate were found in only two parenteral nutrition subjects. Both subjects with elevated D\u2010lactate levels had bone pain, x\u2010ray evidence of fractures, and biopsy evidence of osteomalacia. These studies suggest that D\u2010lactate accumulation may be a heretofore unappreciated metabolic abnormality associated with metabolic bone disease and acidosis in patients with malabsorption who are supported by long\u2010term parenteral nutrition. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>13<\/jats:bold>:132\u2013135, 1989)<\/jats:p>","DOI":"10.1177\/0148607189013002132","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"132-135","source":"Crossref","is-referenced-by-count":26,"title":["D\u2010Lactate and Metabolic Bone Disease in Patients Receiving Long\u2010Term Parenteral Nutrition"],"prefix":"10.1002","volume":"13","author":[{"given":"Mitchell A.","family":"Karton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Rettmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Lipkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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