{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:24:07Z","timestamp":1760660647834,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1989,3,1]],"date-time":"1989-03-01T00:00:00Z","timestamp":604713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:p>We investigated: (1) the capacity to digest and tolerate the lactose administered by continuous infusion of intact milk to undernourished tube\u2010fed patients, and (2) the effectiveness of lactose\u2010prehydrolyzed milk, and of the addition of exogenous lactase to milk at infusion time, to reduce lactose maldigestion and increase clinical tolerance. Carbohydrate digestion was evaluated in 10 subjects with the hydrogen breath analysis test during 8 hr of observation. Lactose intolerance was determined by evaluation of subject's symptoms. With the infusion of intact milk (IM), none of the subjects were able to efficiently digest the lactose infused (5.6 \u00b1 0.35 g\/hr, mean \u00b1 SEM) and 86% of them experienced major symptoms of intolerance. With the infusion of lactose\u2010prehydrolyzed milk (HM) and enzyme\u2010added milk (EM) there was a highly significant reduction in lactose maldigestion. More importantly, major symptoms were present in only 10% of subjects with EM, and were completely eliminated with HM. Lactose maldigestion and intolerance represent a major limitation for the application of milk\u2010based polymeric formula for liquid diets in undernourished subjects. The use of exogenous beta\u2010galactosidases represents an alternative to avoid such reactions. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>13<\/jats:bold> :157\u2013161, 1989)<\/jats:p>","DOI":"10.1177\/0148607189013002157","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"157-161","source":"Crossref","is-referenced-by-count":9,"title":["Lactose Digestion and Clinical Tolerance to Milk, Lactose\u2010Prehydrolyzed Milk and Enzyme\u2010Added Milk: A Study in Undernourished Continuously Enteral\u2010Fed Patients"],"prefix":"10.1002","volume":"13","author":[{"given":"Jorge 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