{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:50:05Z","timestamp":1760885405241,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1989,5,1]],"date-time":"1989-05-01T00:00:00Z","timestamp":609984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>We performed isotopic infusions in 51 surgical patients to investigate the effectiveness of different substrates to conserve protein. All patients were initially studied in the basal state and then the effects of glucose infusion (GL, N = 13), lipid infusion (LIP, N = 11), or amino acid infusion (AA, N = 17) were determined. Ten patients receiving total parenteral nutrition (TPN) were also studied. The basal value for net protein catabolism (NPC) in GL patients was 1.53 \u00b1 0.4 (SEM) g\/kg\/day decreasing to 1.39 \u00b1 0.4 g\/kg\/day during glucose infusion (<jats:italic>p<\/jats:italic> &lt; 0.01). The basal NPC in the LIP group was 2.04 \u00b1 0.4 g\/kg\/day decreasing to 1.72 \u00b1 0.3 g\/kg\/day during lipid infusion (<jats:italic>p<\/jats:italic> &lt; 0.01). In the TPN patients the NPC was 0.79 \u00b1 0.46 g\/kg\/day whereas in the AA patients the basal value for NPC was 1.37 \u00b1 0.14 g\/kg\/day decreasing to \u20100.77 \u00b1 0.11 g\/kg\/day during amino acid infusion (<jats:italic>p<\/jats:italic> &lt; 0.0005). From our study we conclude that: (1) All substrates commonly used in intravenous feeding have the capacity to spare protein. (2) Protein sparing was more pronounced when a balanced amino acid infusion was used than with either glucose or lipid infusion alone. (3) This effect is not solely due to insulin secretion as larger insulin responses were seen with both GL and TPN patients. (4) These results may have implications for peripheral vein feeding with amino acid solutions where there is a contraindication for full TPN or the lack of resources for administering it. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>13<\/jats:bold>: 223\u2013227, 1989)<\/jats:p>","DOI":"10.1177\/0148607189013003223","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"223-227","source":"Crossref","is-referenced-by-count":17,"title":["Relative Importance of Amino Acid Infusion as a Means of Sparing Protein in Surgical Patients"],"prefix":"10.1002","volume":"13","author":[{"given":"David A.","family":"Humberstone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnathan","family":"Koea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.F.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,5]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_1_2_1","DOI":"10.1001\/jama.1936.02770060032009"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1001\/archsurg.1979.01370260011001"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1016\/S0140-6736(82)90212-4"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1002\/1097-0142(197503)35:3<606::AID-CNCR2820350310>3.0.CO;2-B"},{"volume-title":"Chemical Anatomy, Physiology, and Pathology of Extracellular Fluids: A Lecture Syllabus","year":"1947","author":"Gamble JL","key":"e_1_2_1_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1016\/0002-9610(73)90080-9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1001\/archsurg.1987.01400190026005"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_1","DOI":"10.1002\/1097-0142(19860701)58:1<147::AID-CNCR2820580126>3.0.CO;2-I"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_1","DOI":"10.1097\/00000658-198008000-00009"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_1","DOI":"10.1177\/0148607187011002109"},{"key":"e_1_2_1_12_1","first-page":"557","article-title":"Assessment of alanine, urea, and glucose interrelationships in normal subjects and in patients with sepsis using stable isotopes","volume":"97","author":"Shaw JHF","year":"1985","journal-title":"Surgery"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_1","DOI":"10.1111\/j.1749-6632.1959.tb44923.x"},{"key":"e_1_2_1_14_1","first-page":"181","article-title":"Glucose and urea kinetics in patients with early and advanced gastrointestinal cancer: The response to glucose infusion and total parenteral nutrition","volume":"101","author":"Shaw JHF","year":"1987","journal-title":"Surgery"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_1","DOI":"10.1097\/00000658-198612000-00008"},{"key":"e_1_2_1_16_1","first-page":"53","article-title":"Energy and protein metabolism in sarcoma patients","volume":"207","author":"Shaw JHF","year":"1988","journal-title":"Ann Surg"},{"doi-asserted-by":"publisher","key":"e_1_2_1_17_1","DOI":"10.1002\/1097-0142(19820315)49:6<1092::AID-CNCR2820490606>3.0.CO;2-9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_18_1","DOI":"10.1002\/1097-0142(19840315)53:6<1246::AID-CNCR2820530605>3.0.CO;2-D"},{"doi-asserted-by":"publisher","key":"e_1_2_1_19_1","DOI":"10.1177\/0148607184008002146"},{"doi-asserted-by":"publisher","key":"e_1_2_1_20_1","DOI":"10.1177\/014860717900300606"},{"doi-asserted-by":"publisher","key":"e_1_2_1_21_1","DOI":"10.1177\/0148607188012005433"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607189013003223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:57:14Z","timestamp":1760641034000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607189013003223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,5]]}},"alternative-id":["10.1177\/0148607189013003223"],"URL":"https:\/\/doi.org\/10.1177\/0148607189013003223","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}