{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:19:12Z","timestamp":1790018352692,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p>The effects of two kinds of total parenteral nutrition (TPN) on energy and protein metabolism were examined in rats subjected to 15% full\u2010thickness scald burns in the absence of septic complications. One type of TPN was enriched in branched\u2010chain amino acids (BCAAs), especially leucine (45% BCAA content), and the other was conventional TPN (21% BCAA content). Burned rats received isocaloric and isonitrogeneous TPN solutions for 48 hr after resuscitation by saline infusion for 24 hr. Liver and rectus abdominis muscle were removed from the rats at 7, 24, 48, and 72 hr. The concentrations of adenine nucleotides, RNA, protein, glucose\u20106\u2010phosphate, hepatic glycogen, muscle phosphocreatine, and 3\u2010methylhistidine were determined. Metabolic alterations occurred during the period of saline resuscitation (0\u201324 hr). At 48 hr the RNA and protein levels were significantly more improved in the BCAA\u2010TPN group than in the conventional TPN group. At 72 hr, however, the results for the two groups were similar in most metabolite levels. Thus, BCAA\u2010TPN enriched in leucine rapidly stimulated protein synthesis in the liver and muscle. This rapid effect may make it useful during the initial nutritional management of severe trauma patients. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>13:<\/jats:bold>484\u2013489,1989)<\/jats:p>","DOI":"10.1177\/0148607189013005484","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"484-489","source":"Crossref","is-referenced-by-count":9,"title":["Immediate Stimulation of Protein Metabolism in Burned Rats by Total Parenteral Nutrition Enriched in Branched\u2010Chain Amino 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