{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T13:45:53Z","timestamp":1794577553731,"version":"4.9.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>Intravenous fat (Intralipid) is used extensively as a major component of parenteral nutrition for patients in the neonatal intensive care unit. Abnormalities of polymorphonuclear leukocyte (PMN) and platelet number or function related to Intralipid infusion have been reported although conflicting results exist. In order to examine potential adverse hematologic effects of Intralipid, 10 ill neonates were studied before and after a 16\u2010hr infusion of 1 g\/kilo of Intralipid. PMN count, chemokinesis, chemotaxis, and aggregation were unchanged pre\u2010 and post intralipid infusion. Platelet count, bleeding time, and platelet aggregation were also unchanged. Similar results were obtained <jats:italic>in vitro<\/jats:italic> when neonatal and adult PMNs and platelets were incubated in Intralipid and their function analyzed. These findings suggest that short\u2010term, low\u2010dose Intralipid has no measurable impact on neonatal PMN or platelet activity and support its use in neonates even in the presence of infection or thrombocytopenia. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>13:<\/jats:bold>620\u2013622, 1989)<\/jats:p>","DOI":"10.1177\/0148607189013006620","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"620-622","source":"Crossref","is-referenced-by-count":28,"title":["Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function"],"prefix":"10.1002","volume":"13","author":[{"given":"Victor C.","family":"Herson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Block","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Eisenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eufronio G.","family":"Maderazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1989,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1542\/peds.66.1.26","article-title":"Decreased oxygenation and hyperlipemia during intravenous fat infusions in premature infants","volume":"66","author":"Pereira GR","year":"1980","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80248-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607185009002144"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90171-3"},{"key":"e_1_2_1_6_1","first-page":"21","article-title":"Mechanisms of intralipid effect on polymorphonuclear leukocytes","volume":"11","author":"Cleary TG","year":"1983","journal-title":"J Clin Lab Immunol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80019-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80247-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198506000-00022"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80547-X"},{"key":"e_1_2_1_11_1","first-page":"340","volume-title":"Manual of Neonatal Care","author":"Cloherty JP","year":"1981"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/74.1.73"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198604000-00004"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90132-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)93031-7"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(77)90592-9"},{"key":"e_1_2_1_17_1","first-page":"460","article-title":"The effect of intravenous safflower oil emulsion on the clotting mechanism","volume":"49","author":"VanWay CW","year":"1983","journal-title":"Am J Surg"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.58.677.152"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000175324"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607184008004447"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607189013006620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:52:46Z","timestamp":1760633566000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607189013006620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1177\/0148607189013006620"],"URL":"https:\/\/doi.org\/10.1177\/0148607189013006620","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}