{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:50:53Z","timestamp":1760982653618,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1990,5,1]],"date-time":"1990-05-01T00:00:00Z","timestamp":641520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p>To evaluate the efficacy of supplemental arginine with nutritional support in the presence of sepsis, eighty\u2010eight gastrostomized female Hartley guinea pigs were implanted with osmotic pumps effusing an <jats:italic>Eschericia coli\/Staphylococcus aureus<\/jats:italic> mixture. Animals were randomized and infused for two weeks with isocaloric and isovolumetric diets containing 0%, 2%, 4%, or 6% supplemental arginine as arginine hydrochloride. Survival was 12\/22 (54%) in 0%, 9\/22 (41%) in 2% and 4%, and 2\/22 (9%) in 6%. Analysis by chi\u2010square test of independence was significant (<jats:italic>p<\/jats:italic> = 0.0141) with 6% survival lower than the others. Median survival was 11 days in 0%, 8 days in 2% and 6%, and 9 days in 4%. Median survival was longer in 0% than in 2% or 6% (Kruskal\u2010Wallis ANOVA: <jats:italic>p<\/jats:italic> = 0.02). Nitrogen balance was significantly lower in 6% compared to 0% on days 2 through 10, and lower than 2% and 4% on days 6 and 9. Nitrogen balance was higher in 0% than in 2% on days 4, 6, 10, and 13. Serum albumin and C<jats:sub>3<\/jats:sub> were lower in all experimental groups than normal controls (ANOVA: p = 0.01). Comparison of liver, spleen, adrenals, gastrocnemius, and carcass weights, cell\u2010mediated immunity as determined by contact sensitivity to DNFB, and transferrin showed no significant differences. There was a positive dose\u2010response effect seen amongst the experimental groups for the amino acids arginine, ornithine, and citrulline in relation to the amount of supplemental arginine. This study suggests that dietary arginine supplementation does not enhance survival in a guinea pig model of established peritonitis. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>14<\/jats:bold>:237\u2013244, 1990)<\/jats:p>","DOI":"10.1177\/0148607190014003237","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"237-244","source":"Crossref","is-referenced-by-count":53,"title":["Arginine Supplementation and Its Effect on Established Peritonitis in Guinea Pigs"],"prefix":"10.1002","volume":"14","author":[{"given":"Sara J.","family":"Gonce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Peck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Restoration cell\u2010mediated immunity by immunomodulating drugs","volume":"95","author":"Hansbrough J.","year":"1984","journal-title":"Surgery"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198111000-00011"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1093\/jn\/114.9.1697","article-title":"Improvement of nitrogen retention by arginine and glycine supplementation and its relation to collagen synthesis in traumatized mature and aged rats","volume":"114","author":"Chyux J.","year":"1984","journal-title":"J Nutr"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/jn\/111.7.1265","article-title":"Nitrogen retention, muscle creatinine and orotic acid excretion in traumatized rats fed arginine and glycine enriched diets","volume":"111","author":"Minuskin ML","year":"1981","journal-title":"J Nutr"},{"volume-title":"Nutrient requirements of laboratory animals","year":"1978","author":"National Research Council.","key":"e_1_2_1_23_1"},{"key":"e_1_2_1_24_1","first-page":"105","article-title":"Mixed lymphocyte culture supernatants provide effective immunotherapy for acute peritonitis in immunosuppressed rats","volume":"37","author":"MacPhee MJ","year":"1986","journal-title":"Surg Forum"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111763"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.169.4.1467"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1989.01410120062013"},{"key":"e_1_2_1_28_1","first-page":"364","article-title":"Evidence that the activation of Kupffer cells results in the production of L\u2010arginine metabolites that release cell\u2010associated iron and inhibit hepatocyte protein synthesis","volume":"106","author":"Billiar TR","year":"1989","journal-title":"Surgery"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607190014003237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:44:38Z","timestamp":1760622278000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607190014003237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1177\/0148607190014003237"],"URL":"https:\/\/doi.org\/10.1177\/0148607190014003237","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}