{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:53:53Z","timestamp":1764996833012,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1991,3,1]],"date-time":"1991-03-01T00:00:00Z","timestamp":667785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>The use of total parenteral nutrition in bone marrow transplant (BMT) recipients is well recognized. These patients as a result of treatment with chemotherapy and immunosuppressive agents undergo catabolic stress. The metabolic effect of an increased nitrogen dose during total parenteral nutrition (TPN) was studied in 28 BMT patients. Patients were given TPN formulas providing a nitrogen intake of either 267 \u00b1 44 mg of N\/kg\/d or 330 \u00b1 60 mg of N\/kg\/d. Total calories, nonprotein and protein, were held constant at 40 kcal\/ kg\/d for all patients. Data was collected for three periods posttransplant beginning at 3 days posttransplant through day 16. Both study TPN formulas improved patient weight and TIBC values over baseline. Nitrogen balance (NB) values were not significantly different at any study period. However, an overall group effect favored the H\u2010N formula <jats:italic>(p<\/jats:italic> &lt; 0.01). BMT patients undergo catabolic stress which was reflected by average values of 24\u2010hour urine urea nitrogen increasing from 8.1 \u00b1 4 g\/d at baseline to 19.8 \u00b1 7.2 g\/d at period 3 <jats:italic>(p<\/jats:italic> &lt; 0.01). The H\u2010N formula did not differentially increase blood urea nitrogen or serum creatinine levels. Metabolic cart measures also showed no increase in metabolic rate, oxygen consumption, carbon dioxide production, or percent contribution of protein to total metabolic expenditure. Providing a caloric intake of 40 kcal\/ kg\/d was excessive, where 30 to 35 kcal\/kg\/d would meet metabolic demands. Pertinent clinical outcomes including length of stay, relapse rate, and survival were monitored, but no conclusions could be drawn in this study. The H\u2010N formula was more effective in reducing loss of lean body mass without causing detrimental metabolic effects in BMT patients. <jats:italic>(Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>15:<\/jats:bold>184\u2013188, 1991)<\/jats:p>","DOI":"10.1177\/0148607191015002184","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"184-188","source":"Crossref","is-referenced-by-count":34,"title":["Parenteral Nutrition for Marrow Transplant Recipients: Evaluation of an Increased Nitrogen Dose"],"prefix":"10.1002","volume":"15","author":[{"given":"Charles B.","family":"Geibig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"PontingG Owens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay M.","family":"Mirtallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"Nahikian\u2010Nelms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Tutschka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718601000188"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607183007002136"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/ajcn\/46.6.1040","article-title":"Parenteral nutrition in septic patients: Effect of increasing nitrogen intake","volume":"46","author":"Greig P.","year":"1987","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198302000-00007"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198708000-00005"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1177\/014860717900300609","article-title":"Metabolic response to injury and illness: Estimation of energy and protein needs from indirect calorimetry and nitrogen balance","volume":"3","author":"Long C.","year":"1979","journal-title":"JPEN"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(75)90121-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718801200120"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010005441"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607185009002139"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013004373"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010005453"},{"key":"e_1_2_1_14_1","first-page":"43","volume-title":"A Pocket Manual of Surgical Nutrition","author":"Cerra F.","year":"1984"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607187011002112"},{"key":"e_1_2_1_16_1","first-page":"363","article-title":"The biological characteristics of cytokines and their implication in surgical injury","volume":"170","author":"Fong Y.","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860718500900142"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607191015002184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T15:41:25Z","timestamp":1760629285000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607191015002184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["10.1177\/0148607191015002184"],"URL":"https:\/\/doi.org\/10.1177\/0148607191015002184","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"type":"print","value":"0148-6071"},{"type":"electronic","value":"1941-2444"}],"subject":[],"published":{"date-parts":[[1991,3]]}}}