{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:55:56Z","timestamp":1784328956697,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>Early enteral feeding after injury is important for maintenance of gut integrity. However, enteral nutrients are frequently administered at low rates because of decreased gastrointestinal motility. These low rates are said to \u201cmaintain the gut.\u201d This study was performed to evaluate the effect of rate of enteral nutrient delivery on gut mass.<\/jats:p><jats:p>Six male Sprague\u2010Dawley rats had no surgery and served as controls (<jats:italic>ad libitum<\/jats:italic> rat chow diet). Twenty\u2010four male Sprague\u2010Dawley rats underwent abdominal surgery for placement of gastroduodenal feeding tubes (tip located 2 cm into intestine from pylorus) and were randomized (n = 6 per group) <jats:italic>to ad libitum<\/jats:italic> rat chow, 1\/2 strength peptide diet (Reabilan HN, RHN) at 1 mL\/h (1\/2RHN\u20101 mL), full\u2010strength peptide diet at 2 mL\/h (RHN\u20102 mL), or full\u2010strength peptide diet at 4 mL\/ h (RHN\u20104 mL). These diets supplied approximately 30%, 13%, 50%, and 100% of rat recommended daily allowances.<\/jats:p><jats:p>The control animals gained weight (38 \u00b1 3 g over 5 days) whereas all postsurgery animals lost weight. Weight loss was greatest in the 1\/2 RHN\u20101 mL (\u201055 \u00b1 3 g over 5 days) and RHN\u20102 mL (\u201052 \u00b1 6 g over 5 days) groups compared with the RHN\u20104 mL animals (\u201041 \u00b1 5 g over 5 days). All animals fed liquid enteral diets had reduced gut weights compared with chow\u2010fed animals. Gut weights did not differ between control and postsurgery <jats:italic>ad libitum<\/jats:italic> chow animals. Proximal gut mucosal protein content was significantly (<jats:italic>p<\/jats:italic> &lt;.05) higher in the RHN\u20104 mL animals (0.88 \u00b1 0.03 mg\/cm) compared with control (0.74 \u00b1 0.003 mg\/cm) and <jats:italic>ad libitum<\/jats:italic> chow animals (0.73 \u00b1 0.05 mg\/ cm). There were no differences in mid\u2010 and distal gut mucosal protein levels between groups. We conclude that the rate of enteral feeding has little effect on gut mass in the early (5 day) postoperative period in rats. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> 16:39\u201342, 1992)<\/jats:p>","DOI":"10.1177\/014860719201600139","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"39-42","source":"Crossref","is-referenced-by-count":27,"title":["Effect of Rate of Enteral Nutrient Supply on Gut Mass"],"prefix":"10.1002","volume":"16","author":[{"given":"Gary P.","family":"Zaloga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Ward Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Prielipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1992,1]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1180","article-title":"What to consider when choosing enteral or parenteral nutrition","volume":"5","author":"Zaloga GP","year":"1990","journal-title":"J Crit Illness"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-198610000-00003"},{"key":"e_1_2_1_4_1","first-page":"556","article-title":"Immediate postoperative enteral feeding improves wound healing following abdominal surgery in rats","volume":"19","author":"Bortenschlager L.","year":"1991","journal-title":"Crit Care Med"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630-198403000-00004"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198409000-00007"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/ajcn\/39.1.45","article-title":"Immune response and leucine oxidation in oral and intravenous fed rats","volume":"39","author":"Birkhahn RH","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_8_1","first-page":"10S","article-title":"Effect of parenteral nutrition on gut IgA plasma cells","volume":"14","author":"Alverdy JC","year":"1990","journal-title":"JPEN"},{"key":"e_1_2_1_9_1","first-page":"22S","article-title":"Enteral feeding reduces postoperative septic complications","volume":"15","author":"Moore F.","year":"1991","journal-title":"JPEN"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/ajcn\/51.6.1035","article-title":"Very early nutrition supplementation in burned patients","volume":"5","author":"Chiarelli A.","year":"1990","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_11_1","first-page":"22S","article-title":"Enteral feeding during operative procedures","volume":"15","author":"Jenkins M.","year":"1991","journal-title":"JPEN"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/014860719101500142"},{"key":"e_1_2_1_13_1","first-page":"26S","article-title":"Trophic effect of dietary peptides on mucosa in the rat small bowel","volume":"14","author":"Birke H.","year":"1990","journal-title":"JPEN"},{"key":"e_1_2_1_14_1","first-page":"29S","article-title":"Dietary protein prevents bacterial translocation from the gut","volume":"15","author":"Shou J.","year":"1991","journal-title":"JPEN"},{"key":"e_1_2_1_15_1","first-page":"556","volume-title":"Clinical Nutrition: Enteral and Tube Feeding","author":"Palaccio JC","year":"1990"},{"key":"e_1_2_1_16_1","first-page":"G378","article-title":"Effect of dietary fibers on rat large bowel mucosal growth and cell proliferation","volume":"246","author":"Jacobs LR","year":"1984","journal-title":"Am J Physiol"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860719201600139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:53:38Z","timestamp":1760640818000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860719201600139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1177\/014860719201600139"],"URL":"https:\/\/doi.org\/10.1177\/014860719201600139","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}