{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:18:32Z","timestamp":1763036312925,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>Selenium (Se) is not routinely included in total parenteral nutrition (TPN) solution; thus, patients receiving long\u2010term TPN may be at risk of Se deficiency, which may cause fatal cardiomyopathy. Platelet glutathione peroxidase (GSH\u2010Px) activity, as well as Se levels and GSH\u2010Px activity in plasma and erythrocytes during prolonged TPN, was measured in six patients with chronic gastrointestinal disease. During the time course of TPN, Se administration was discontinued for 12 weeks, and then resupplemented for another 12 weeks. Before the study period, all Se indices had been maintained within the normal range. After discontinuation of Se supplementation, a significant decrease in platelet GSH\u2010Px activity was observed after 1 week (from 64 \u00b1 7 [mean \u00b1 SD] to 39 \u00b1 5 U\/g of protein). After resupplementation, it increased after 1 week (from 44 \u00b1 9 to 65 \u00b1 10 U\/g of protein). Plasma Se indices significantly changed within 3 weeks after withdrawal and reintroduction of Se (Se: from 136 \u00b1 28 to 75 \u00b1 14 and from 61 \u00b1 22 to 125 \u00b1 33 \u03bcg\/L; GSH\u2010Px: from 236 \u00b1 50 to 140 \u00b1 36 and from 128 \u00b1 32 to 220 \u00b1 64 U\/L). Erythrocyte Se indices showed no significant changes during the study period. The results demonstrate that platelet GSH\u2010Px activity is the most sensitive index of Se status in TPN patients. 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