{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:41:05Z","timestamp":1760636465494,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:p>Polyamines, synthesized by all mammalian cells, are involved in protein and energy metabolism. We measured urinary excretion of polyamines, putrescine, spermidine, spermine, and their metabolites <jats:italic>N<\/jats:italic> <jats:sup>1<\/jats:sup>\u2010acetylspermidine and <jats:italic>N<\/jats:italic> <jats:sup>8<\/jats:sup>acetylspermidine, resting energy expenditure, and nitrogen excretion in 12 depleted patients with gastrointestinal malignancy during preoperative and postoperative parenteral nutrition and in 7 patients with multiple trauma receiving similar parenteral nutrition. During preoperative nutrition support, the excretion of putrescine (<jats:italic>p<\/jats:italic> &lt;.05) and total polyamines (<jats:italic>p<\/jats:italic> &lt;.01) increased by 420% and 60%, respectively. Increases in energy balance and resting energy expenditure during nutrition could entirely explain the observed changes in polyamine excretion. Preoperatively, the excretion of <jats:italic>N<\/jats:italic> <jats:sup>1<\/jats:sup>\u2010acetylspermidine (<jats:italic>p<\/jats:italic> &lt;.05), <jats:italic>N<\/jats:italic> <jats:sup>8<\/jats:sup>acetylspermidine (<jats:italic>p<\/jats:italic> &lt;.001) and total polyamines (<jats:italic>p<\/jats:italic> &lt;.05) was higher in patients with a surgically noncurable tumor than in those with a surgically curable tumor. The energy balance and resting energy expenditure could also explain the differences in polyamine excretion between patients with surgically curable and noncurable disease, excluding the increased <jats:italic>N<\/jats:italic> <jats:sup>8<\/jats:sup>\u2010acetylspermidine. Postoperatively, the excretion of <jats:italic>N<\/jats:italic> <jats:sup>8<\/jats:sup>\u2010acetylspermidine in patients with multiple trauma without malignancy and in patients with palliative operation was similar, and was higher than in patients with a totally resected malignancy (<jats:italic>p<\/jats:italic> &lt;.01). Our results suggest that the excretion of polyamines reflects the activity of energy metabolism in general and that polyamine excretion is not specific for any particular disease. 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