{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:49:20Z","timestamp":1762505360830,"version":"build-2065373602"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1992,9,1]],"date-time":"1992-09-01T00:00:00Z","timestamp":715305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:p>One hundred and forty silicone catheters were inserted in 127 patients for long\u2010term intravenous access with a cumulative follow\u2010up time of 21,125 catheter\u2010days (58 patient\u2010years). Fifty\u2010six patients had acquired immunodeficiency syndrome (AIDS); 44 were not AIDS patients and were receiving ambulatory home parenteral nutrition, whereas the remaining 27 did not have AIDS and were receiving home antibiotic therapy. Patients had a mean of 1.1 catheters inserted, and the rate of Hickman catheter\u2010related sepsis was 0.18 per 100 catheter days or 0.6 septic episodes per patient year of treatment. Catheter\u2010related sepsis was higher in AIDS patients (<jats:italic>p<\/jats:italic> &lt;.01) and in patients receiving parenteral nutrition (<jats:italic>p<\/jats:italic> &lt;.05) compared with those receiving antibiotic therapy. Prior catheter infection and AIDS were the most significant predictors of catheter infection (<jats:italic>p<\/jats:italic> &lt;.01). Staphylococcus aureus was the most commonly isolated pathogen (61%) in AIDS patients. Fever (<jats:italic>p<\/jats:italic> &lt;.001) and relative leukocytosis (<jats:italic>p<\/jats:italic> &lt;.02) were the most common signs of infection. Only 14 infected catheters (37.8%) were salvaged by antibiotic therapy after the initial infection episode, and 6 of these catheters (42.9%) had recurrent multiple infections. In addition, inflammatory bowel disease was found to be a risk factor for venous thrombosis (<jats:italic>p<\/jats:italic> =.018). We conclude that because immunocompromised patients have a high risk of infection, catheter\u2010related sepsis in these patients should be treated by catheter removal and antibiotics. 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