{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:04:42Z","timestamp":1787018682063,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>\n                    Our purpose was to extend previous studies of the stability of vitamins A (retinol palmitate), E (tocopherol acetate), and K\n                    <jats:sub>1<\/jats:sub>\n                    (phylloquinone) to total parenteral nutrition at\u2010home (TPNH) admixtures. First, stability over 20 days was tested. Experimental conditions included presence or absence of lipids, presence or absence of trace elements, and storage in a glass bottle or in a single or multi\u2010layer plastic bag (ethylene vinyl acetate, polyvinyl chloride, Stedim 5, and Stedim 6). The 20\u2010day storage studies were conducted at 4\u00b0C or at ambient air temperature. The second part of the study consisted of exposing to natural light TPNH admixtures with or without lipids, but with trace elements, in the same containers (except polyvinyl chloride). Finally, a clinical situation of TPNH was simulated with a TPNH admixture prepared 11 days before the test in a Stedim 6 plastic bag and stored at 4\u00b0C in total darkness. For vitamins A, E, and K\n                    <jats:sub>1<\/jats:sub>\n                    , we observed good stability for 20 days; the final concentrations ranged from 75% to 100% of initial concentrations whatever the conditions studied. It appears that there is no significant difference of action between all containers and that the presence or absence of lipids and trace elements in admixtures stored at 4\u00b0C or ambient temperature makes no difference. With exposure to sunlight, vitamin losses were 100% at 3 hours for vitamin A and 50% for vitamin K\n                    <jats:sub>1<\/jats:sub>\n                    ; vitamin E concentrations were unchanged after 12 hours of experiment. The presence of lipids or type of container did not appear to enhance protection from direct sunlight. Finally, we showed that, under standardized conditions of preparation, storage, and administration of TPNH such as those used in the pharmaceutical department of Debrousse Hospital, the amounts of vitamins A, E, and K\n                    <jats:sub>1<\/jats:sub>\n                    that were administered to patients adequately corresponded to the amounts of vitamins prescribed and added to TPN admixtures. (Journal of Parenteral and Enteral Nutrition 17:56\u201360, 1993)\n                  <\/jats:p>","DOI":"10.1177\/014860719301700156","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"56-60","source":"Crossref","is-referenced-by-count":41,"title":["Stability of Fat\u2010Soluble Vitamins A (Retinol Palmitate), E (Tocopherol Acetate), and K1 (Phylloquinone) in Total Parenteral Nutrition at Home"],"prefix":"10.1002","volume":"17","author":[{"given":"F.","family":"Billion\u2010Rey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guillaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Frederich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Aulagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-4-576"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1973.03220030062030"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80288-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/ajcn\/40.1.8","article-title":"Vitamin A losses to plastic intravenous infusion devices and an improved method of delivery","volume":"40","author":"Gutcher GR","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607185009005568"},{"key":"e_1_2_1_7_1","first-page":"271","article-title":"Vitamin stability in a TPN mixture stored in an E.V","volume":"11","author":"Dahl GB","year":"1986","journal-title":"A. plastic bag. J Clin Hosp Pharm"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0261-5614(88)90369-X"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5173(84)90163-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607188012004394"},{"key":"e_1_2_1_11_1","volume-title":"Statwork Logical, Data\u2010metrics","author":"Rafferty J.","year":"1987"},{"key":"e_1_2_1_12_1","first-page":"201","article-title":"Study of the retention of child dose drugs on cellulose ester membranes during in\u2010line intravenous filtration","volume":"1","author":"Vu Khue N.","year":"1985","journal-title":"STP Pharm"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607182006005403"},{"key":"e_1_2_1_14_1","first-page":"83","volume-title":"Sorption of drugs to intravenous delivery systems","author":"Allwood MC","year":"1983"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600711003"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607186010002245"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1542\/peds.58.3.448","article-title":"Vitamin delivery in total parenteral nutrition solutions","volume":"58","author":"Hartline JN","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_1_18_1","first-page":"1561","article-title":"Loss of vitamin A from total parenteral nutrition solutions","volume":"39","author":"McKenna MC","year":"1980","journal-title":"Fed Proc"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/014860719301700156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:16:14Z","timestamp":1760642174000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/014860719301700156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1177\/014860719301700156"],"URL":"https:\/\/doi.org\/10.1177\/014860719301700156","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}