{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:16:28Z","timestamp":1791393388491,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>This is a case report on six patients with hyperammonemia that developed while they were receiving total parenteral nutrition (TPN) as a component of renal failure therapy. Clinically, the hyperammonemia presented as mental status changes in all six cases. Four of the six patients with renal failure initially received 400 mL Amiyu in 1400 mL 17% glucose (total = 1800 mL TPN\u2010A) administered over each 24\u2010hour period. Two patients had been placed on 400 mL complete amino acid in 1400 mL 17% glucose (total = 1800 mL TPN\u2010C over each 24\u2010hour period) prior to therapy with TPN\u2010A. Approximately 3 weeks after initiation of TPN therapy with TPN\u2010A, episodes of mental status changes of increasing duration and paroxysms were documented in five of the six patients. In one of the patients receiving TPN\u2010C prior to TPN\u2010A therapy, toxicity was clinically evident only 4 days after initiation of TPN\u2010A. Serum ammonia levels were obtained and found to be elevated in the acute (ie, presenting) stage in all patients. With the discontinuance of TPN\u2010A, ammonia levels normalized uniformly. Mental status also improved in all cases except for the patient with rapid clinical presentation who died 2 weeks after first evidence of clinical toxicity. In cases 1, 2, and 6, serum amino acid analysis in the acute phase showed reduced levels of ornithine and citrulline, the substrate and product, respectively, of condensation with carbamyl phosphate at its entry into the urea cycle. Moreover, levels of arginine, precursor to ornithine, were found to be elevated. And, in cases 1 and 6, the serum concentration of orotic acid was 40 times and 23 times, respectively, the value expected in a normal healthy adult. This is presumably due to funneling of carbamyl phosphate into an alternate biosynthetic pathway as a result of inadequate ornithine needed as substrate for its entrance into the urea cycle. Thus, the common denominator in the hyperammonemia experienced in these cases appears to be a depletion of ornithine stores, which we hypothesize to have mainly resulted from inhibition of arginosuccinate synthetase by histidine. Consequently, in patients requiring long\u2010term TPN therapy (&gt;3 weeks in our experience with TPN\u2010A), it may be necessary to supplement ornithine in addition to arginine. In all such patients, we feel it is necessary to monitor serum ammonia for toxicity or long\u2010term elevation. 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Failure"],"prefix":"10.1002","volume":"17","author":[{"given":"Hisao","family":"Nakasaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokitaka","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seishichi","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Mitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Suga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Fuj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1542\/peds.48.6.955","article-title":"Biochemical 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