{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T19:35:51Z","timestamp":1769628951109,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Parenter Enteral Nutr"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>The timing of the first meconium stool has been considered a marker for proper gastrointestinal functioning in the term infant. There is limited information on the meconium passage patterns of very\u2010low\u2010birth\u2010weight infants of less than 32 weeks' gestation. It is unknown whether feeding practices influence the timing of the first stool in these infants. We retrospectively studied 47 very\u2010low\u2010birth\u2010weight infants with birth weights of 1250 g or less who were previously enrolled in a study of gastrointestinal (GI) priming. Infants whose mothers desired to breast feed (n = 7) were given GI priming with their own mother's milk. The remaining infants had been randomly assigned to receive total parenteral nutrition alone (n = 21) or GI priming with infant formula (n = 19) during the first 14 days of life. We attempted to advance all infants to full enteral nutrition by 21 days of age. There was no statistically significant difference in timing of the first stool among the three groups. The overall median age at first stool was 43 hours, and the 75th percentile was 10 days. The range was 1\/2 hour to 27 days. There was no concordance between time of first stool and birth weight within the range studied. There was no concordance between time of first stool and necrotizing enterocolitis, although there was little statistical power to detect this. There was also very little concordance with feeding tolerance. Other than necrotizing enterocolitis, no significant GI disease developed in any of the infants studied. Because meconium passage is delayed past 10 days in 25% of the infants studied and delayed passage does not seem to predict GI disease, there is no rationale for extensive investigation or treatment of delayed meconium passage in very\u2010low\u2010birth\u2010weight infants unless there are other signs of GI disease. (<jats:italic>Journal of Parenteral and Enteral Nutrition<\/jats:italic> <jats:bold>17:<\/jats:bold>537\u2013540, 1993)<\/jats:p>","DOI":"10.1177\/0148607193017006537","type":"journal-article","created":{"date-parts":[[2008,5,14]],"date-time":"2008-05-14T19:51:26Z","timestamp":1210794686000},"page":"537-540","source":"Crossref","is-referenced-by-count":26,"title":["Meconium Passage in Very\u2010Low\u2010Birth\u2010Weight Infants"],"prefix":"10.1002","volume":"17","author":[{"given":"William H.","family":"Meetze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie L.","family":"Palazzolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Bowling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marylou","family":"Behnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Burchfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Neu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(55)80205-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1542\/peds.60.4.457","article-title":"Times of first void and first stool in 500 newborns","volume":"60","author":"Clark DA","year":"1977","journal-title":"Pediatrics"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.64.1.30","article-title":"Relevance of the gestational age distribution of meconium passage in utero","volume":"64","author":"Matthews TG","year":"1979","journal-title":"Pediatrics"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80186-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1542\/peds.79.6.1005","article-title":"Passage of first stool in very low birth weight infants","volume":"79","author":"Jhaveri MK","year":"1987","journal-title":"Pediatrics"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.4.483"},{"key":"e_1_2_1_8_1","first-page":"224","article-title":"Functional development of the fetal gastrointestinal tract","volume":"13","author":"Neu J.","year":"1980","journal-title":"Semin Perinatol"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80302-6"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80646-2"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199208000-00011"}],"container-title":["Journal of Parenteral and Enteral Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1177\/0148607193017006537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T18:45:14Z","timestamp":1760640314000},"score":1,"resource":{"primary":{"URL":"https:\/\/aspenjournals.onlinelibrary.wiley.com\/doi\/10.1177\/0148607193017006537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1177\/0148607193017006537"],"URL":"https:\/\/doi.org\/10.1177\/0148607193017006537","archive":["Portico"],"relation":{},"ISSN":["0148-6071","1941-2444"],"issn-type":[{"value":"0148-6071","type":"print"},{"value":"1941-2444","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}